Featured Research

from universities, journals, and other organizations

Antioxidants may ease peripheral arterial disease (PAD) blood pressure increase, study suggests

Date:
November 8, 2012
Source:
Penn State
Summary:
Low antioxidant levels contribute to increased blood pressure during exercise for people with peripheral arterial disease (PAD), according to researchers. Their study shows that blood pressure increases more with exercise in more severe PAD cases. By infusing the antioxidant vitamin C into the blood, the researchers were able to lessen the increase in blood pressure during exercise.

Pomegranate fruit is rich in antioxidants.
Credit: © Natika / Fotolia

Low antioxidant levels contribute to increased blood pressure during exercise for people with peripheral arterial disease, according to researchers at Penn State Hershey Heart and Vascular Institute.

Related Articles


Peripheral arterial disease, or PAD, affects an estimated 10 million Americans and increases the chance of death from a cardiovascular event. Reduced blood flow causes pain in the legs and increases blood pressure in people who have PAD. However, the causes of the disease are unknown.

"Past studies have shown that having low antioxidant levels and increased reactive oxygen species -- chemical products that bind to body cells and cause damage -- is related to more severe PAD," said Matthew Muller, postdoctoral fellow in Larry Sinoway's lab at Penn State College of Medicine, and lead author of the study.

Antioxidants prevent the reactive oxygen species from damaging cells.

"This study shows that blood pressure increases more with exercise in more severe PAD cases. By infusing the antioxidant vitamin C into the blood, we were able to lessen the increase in blood pressure during exercise," said Muller.

Vitamin C does not lessen the increase in blood pressure of PAD patients to that of healthy people. As the intensity of exercise increases, the effects of vitamin C decrease but are still seen. The researchers report their findings in the Journal of Physiology.

Penn State Hershey researchers looked at three groups of PAD patients to study the blood pressure increase. A group of 13 PAD patients was compared to people without PAD to see the effects of doing low-intensity exercise on blood pressure. From that group, a second group of nine patients was used to measure the effects of vitamin C. A third group of five PAD patients and five without PAD had their leg muscles electrically stimulated to remove the brain's role in raising blood pressure during muscle contraction in this disease.

Increased blood pressure during exercise occurs in both legs, before pain begins, and relates to the severity of the disease. By using electrical stimulation, the scientists show that the blood pressure increase comes from the muscle itself, since the brain is not telling the leg to contract and the pressure still increases.

"This indicates that during normal, everyday activities such as walking, an impaired antioxidant system -- as well as other factors -- plays a role in the increased blood pressure response to exercise," Muller said. "Therefore, supplementing the diet with antioxidants may help these patients, but more studies are needed to confirm this concept."

Other researchers are Rachel C. Drew, postdoctoral fellow; Cheryl A. Blaha, research coordinator; Jessica L. Mast, research coordinator; Jian Cui, associate professor of medicine; and Amy B. Reed, associate professor of surgery, all of Penn State College of Medicine.

The study was funded by the National Institutes of Health.


Story Source:

The above story is based on materials provided by Penn State. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. D. Muller, R. C. Drew, C. A. Blaha, J. L. Mast, J. Cui, A. B. Reed, L. I. Sinoway. Oxidative Stress Contributes to the Augmented Exercise Pressor Reflex in Peripheral Arterial Disease Patients. The Journal of Physiology, 2012; DOI: 10.1113/jphysiol.2012.241281

Cite This Page:

Penn State. "Antioxidants may ease peripheral arterial disease (PAD) blood pressure increase, study suggests." ScienceDaily. ScienceDaily, 8 November 2012. <www.sciencedaily.com/releases/2012/11/121108181915.htm>.
Penn State. (2012, November 8). Antioxidants may ease peripheral arterial disease (PAD) blood pressure increase, study suggests. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2012/11/121108181915.htm
Penn State. "Antioxidants may ease peripheral arterial disease (PAD) blood pressure increase, study suggests." ScienceDaily. www.sciencedaily.com/releases/2012/11/121108181915.htm (accessed October 26, 2014).

Share This



More Health & Medicine News

Sunday, October 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins