Featured Research

from universities, journals, and other organizations

Stem cell finding could advance immunotherapy for lung cancer

Date:
November 13, 2012
Source:
University of Cincinnati Academic Health Center
Summary:
A lung cancer research team reports that lung cancer stem cells can be isolated -- and then grown -- in a preclinical model, offering a new avenue for investigating immunotherapy treatment options that specifically target stem cells.

Lung cancer stem cells, grown via tumorsphere assay.
Credit: University of Cincinnati

A University of Cincinnati (UC) Cancer Institute lung cancer research team reports that lung cancer stem cells can be isolated -- and then grown -- in a preclinical model, offering a new avenue for investigating immunotherapy treatment options that specifically target stem cells.

Related Articles


John C. Morris, MD, and his colleagues report their findings in the Nov. 13, 2012, issue of PLoS One, a peer-reviewed online publication.

Stem cells are unique cells that can divide and differentiate into specialized cells types -- for example cardiac muscle or liver tissue. These cells also have the ability to self-renew and produce more stem cells.

"Increasing evidence supports the idea that cancerous tumors have a population of stem cells, also called cancer-initiating cells, that continually regenerate and fuel cancer growth," explains Morris, senior author of the study and professor at the UC College of Medicine. "These cancer stem cells may also have the highest potential to spread to other organs."

Current models used to study cancer stem cells provide limited information on the interaction between cancer stem cells with the immune system, making the study of new therapies that utilize the body's immune system to fight off cancer virtually impossible.

In this study, the UC team set out to find a viable, consistent way to isolate lung cancer stem cells that could be used in a mouse model with full immune system function. The team was able to achieve this using a functional laboratory test known as "tumorsphere" assay.

The test -- which shows how cells grow in culture -- allowed them to enrich for cancer stem cells.

"Studying these unique cells could greatly improve our understanding of lung cancer's origins and lead to the novel therapeutics targeting these cells and help to more effectively eradicate this disease," adds Morris. "Immunotherapy is the future of cancer treatment. We are hopeful that this new method will accelerate our investigation of immunotherapies to specifically target cancer stem cells."

The team is working to characterize how cancer stem cells escape the body's immune system in order to develop more effective therapies that target stem cells.

"One of the hypotheses behind why cancer therapies fail is that the drug only kills cells deemed to be 'bad' (because of certain molecular characteristics), but leaves behind stem cells to repopulate the tumor," adds Morris. "Stem cells are not frequently dividing, so they are much less sensitive to existing chemotherapies used to eliminate cells deemed abnormal."

UC study collaborators in this UC-funded study include hematology oncology postdoctoral fellow Brian Morrison, PhD, and Jason Steel, PhD, a lung cancer researcher and assistant professor of research at the UC College of Medicine.


Story Source:

The above story is based on materials provided by University of Cincinnati Academic Health Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Brian J. Morrison, Jason C. Steel, John C. Morris. Sphere Culture of Murine Lung Cancer Cell Lines Are Enriched with Cancer Initiating Cells. PLoS ONE, 2012; 7 (11): e49752 DOI: 10.1371/journal.pone.0049752

Cite This Page:

University of Cincinnati Academic Health Center. "Stem cell finding could advance immunotherapy for lung cancer." ScienceDaily. ScienceDaily, 13 November 2012. <www.sciencedaily.com/releases/2012/11/121113174916.htm>.
University of Cincinnati Academic Health Center. (2012, November 13). Stem cell finding could advance immunotherapy for lung cancer. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2012/11/121113174916.htm
University of Cincinnati Academic Health Center. "Stem cell finding could advance immunotherapy for lung cancer." ScienceDaily. www.sciencedaily.com/releases/2012/11/121113174916.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins