Featured Research

from universities, journals, and other organizations

Arginine and proline enriched diet may speed wound healing in diabetes

Date:
November 15, 2012
Source:
American Physiological Society (APS)
Summary:
A diet enriched with arginine and proline could speed diabetes-related wound healing, a new study suggests.

Chronic wounds such as foot ulcers are a common problem for diabetics and are the cause of more than 80 percent of the lower leg amputations in these patients. There is currently no effective way to improve healing of these types of wounds, but new research offers hope.

French researchers found that diabetic rats on a high protein diet with arginine and proline -- specific molecules found in protein -- showed better wound healing over rats fed either standard or high protein food without arginine and proline supplementation.

The article is entitled "Arginine plus proline supplementation elicits metabolic adaptation that favors wound healing in diabetic rats." It appears in the online edition of the American Journal of Physiology -- Regulatory, Integrative and Comparative Physiology published by the American Physiological Society.

Researchers divided 18 rats into three groups that were either fed a standard diet, a high-protein diet, or a high protein diet supplemented with arginine and proline (ARG+PRO). On the first day of the experiment, each rat was given an incision, under which a sponge was placed in order to collect wound-healing fluid. To assess skin regrowth and healing, researchers also removed two full-thickness sections of skin from the rats' backs each day from day 1 until day 5, when the experiment ended.

At the end of the experiment, the rats' blood was analyzed for blood sugar, insulin, and amino acid concentrations. The wounds on their backs were examined for skin regrowth and development of new blood vessels. And, finally, macrophages were collected from the sponges and analyzed for indications of cytokine stimulation and pro-inflammatory activity.

Rats on both high protein diets had better nitrogen balance than those on the standard diet. However, the wounds of the rats on the ARG+PRO diet showed more new blood vessel growth on day 5. New blood vessel growth is an essential part of wound healing as the blood vessels supply nutrition and oxygen to growing tissue.

Furthermore, the macrophages in the ARG+PRO group showed less cytokine stimulation and pro-inflammatory activity than the other groups. This indicates a better environment for promoting wound healing, as inflammation slows the healing process.

The researchers did not find a difference in skin regrowth between groups, but their findings may be limited because of the small number of rats in the study. Additionally, researchers did not measure markers of collagen deposition in the wound, and the study cannot confirm the beneficial effect of arginine on collagen deposition and wound breaking strength reported in previous research.

This study suggests that arginine and proline supplementation could offer new hope for effective treatment in diabetic patients with chronic wounds. This is a promising new area of research where there are no existing effective treatments for these patients.

The study was conducted by Agathe Raynaud-Simon, Linda Belabed, J. Marc, Luc Cynober, and Sylviane Darquy of the Department of Experimental, Metabolic and Clinical Biology, Paris Descartes University, Paris, France and Gilles Le Naour and Frederique Capron of Piti้-Salp้tri่re Hospital AP-HP, Faculty of Medicine Pierre-et-Marie-Curie, Paris.

This study was supported by an unrestricted grant from Nestl้ Clinical Nutrition.


Story Source:

The above story is based on materials provided by American Physiological Society (APS). Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Raynaud-Simon, L. Belabed, G. Le Naour, J. Marc, F. Capron, L. Cynober, S. Darquy. Arginine plus proline supplementation elicits metabolic adaptation that favors wound healing in diabetic rats. AJP: Regulatory, Integrative and Comparative Physiology, 2012; 303 (10): R1053 DOI: 10.1152/ajpregu.00003.2012

Cite This Page:

American Physiological Society (APS). "Arginine and proline enriched diet may speed wound healing in diabetes." ScienceDaily. ScienceDaily, 15 November 2012. <www.sciencedaily.com/releases/2012/11/121115162135.htm>.
American Physiological Society (APS). (2012, November 15). Arginine and proline enriched diet may speed wound healing in diabetes. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2012/11/121115162135.htm
American Physiological Society (APS). "Arginine and proline enriched diet may speed wound healing in diabetes." ScienceDaily. www.sciencedaily.com/releases/2012/11/121115162135.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) — President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) — A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) — The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) — A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins