Featured Research

from universities, journals, and other organizations

Arginine and proline enriched diet may speed wound healing in diabetes

Date:
November 15, 2012
Source:
American Physiological Society (APS)
Summary:
A diet enriched with arginine and proline could speed diabetes-related wound healing, a new study suggests.

Chronic wounds such as foot ulcers are a common problem for diabetics and are the cause of more than 80 percent of the lower leg amputations in these patients. There is currently no effective way to improve healing of these types of wounds, but new research offers hope.

French researchers found that diabetic rats on a high protein diet with arginine and proline -- specific molecules found in protein -- showed better wound healing over rats fed either standard or high protein food without arginine and proline supplementation.

The article is entitled "Arginine plus proline supplementation elicits metabolic adaptation that favors wound healing in diabetic rats." It appears in the online edition of the American Journal of Physiology -- Regulatory, Integrative and Comparative Physiology published by the American Physiological Society.

Researchers divided 18 rats into three groups that were either fed a standard diet, a high-protein diet, or a high protein diet supplemented with arginine and proline (ARG+PRO). On the first day of the experiment, each rat was given an incision, under which a sponge was placed in order to collect wound-healing fluid. To assess skin regrowth and healing, researchers also removed two full-thickness sections of skin from the rats' backs each day from day 1 until day 5, when the experiment ended.

At the end of the experiment, the rats' blood was analyzed for blood sugar, insulin, and amino acid concentrations. The wounds on their backs were examined for skin regrowth and development of new blood vessels. And, finally, macrophages were collected from the sponges and analyzed for indications of cytokine stimulation and pro-inflammatory activity.

Rats on both high protein diets had better nitrogen balance than those on the standard diet. However, the wounds of the rats on the ARG+PRO diet showed more new blood vessel growth on day 5. New blood vessel growth is an essential part of wound healing as the blood vessels supply nutrition and oxygen to growing tissue.

Furthermore, the macrophages in the ARG+PRO group showed less cytokine stimulation and pro-inflammatory activity than the other groups. This indicates a better environment for promoting wound healing, as inflammation slows the healing process.

The researchers did not find a difference in skin regrowth between groups, but their findings may be limited because of the small number of rats in the study. Additionally, researchers did not measure markers of collagen deposition in the wound, and the study cannot confirm the beneficial effect of arginine on collagen deposition and wound breaking strength reported in previous research.

This study suggests that arginine and proline supplementation could offer new hope for effective treatment in diabetic patients with chronic wounds. This is a promising new area of research where there are no existing effective treatments for these patients.

The study was conducted by Agathe Raynaud-Simon, Linda Belabed, J. Marc, Luc Cynober, and Sylviane Darquy of the Department of Experimental, Metabolic and Clinical Biology, Paris Descartes University, Paris, France and Gilles Le Naour and Frederique Capron of Piti้-Salp้tri่re Hospital AP-HP, Faculty of Medicine Pierre-et-Marie-Curie, Paris.

This study was supported by an unrestricted grant from Nestl้ Clinical Nutrition.


Story Source:

The above story is based on materials provided by American Physiological Society (APS). Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Raynaud-Simon, L. Belabed, G. Le Naour, J. Marc, F. Capron, L. Cynober, S. Darquy. Arginine plus proline supplementation elicits metabolic adaptation that favors wound healing in diabetic rats. AJP: Regulatory, Integrative and Comparative Physiology, 2012; 303 (10): R1053 DOI: 10.1152/ajpregu.00003.2012

Cite This Page:

American Physiological Society (APS). "Arginine and proline enriched diet may speed wound healing in diabetes." ScienceDaily. ScienceDaily, 15 November 2012. <www.sciencedaily.com/releases/2012/11/121115162135.htm>.
American Physiological Society (APS). (2012, November 15). Arginine and proline enriched diet may speed wound healing in diabetes. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2012/11/121115162135.htm
American Physiological Society (APS). "Arginine and proline enriched diet may speed wound healing in diabetes." ScienceDaily. www.sciencedaily.com/releases/2012/11/121115162135.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) — President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) — A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) — A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) — A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins