Featured Research

from universities, journals, and other organizations

Salmonella spreads by targeting cells in our gut, study shows

Date:
December 11, 2012
Source:
University of Edinburgh
Summary:
Scientists have gained fresh insights into how the salmonella bug makes us ill. Researchers have found that the bacteria are able to change key cells that line the intestine, enabling the bugs to thrive.

Scientists have gained fresh insights into how the salmonella bug makes us ill. University of Edinburgh researchers have found that the bacteria are able to change key cells that line the intestine, enabling the bugs to thrive.

By changing the make-up of these cells, the salmonella bacteria are able to cross the gut wall.

Food poisoning

Salmonella food poisoning -- commonly caused by eating undercooked poultry or eggs -- can lead to diarrhea, fever and even death in young children.

Scientists say the study furthers our understanding of how bacterial infections occur and what enables them to spread.

Cellular make-up

The University of Edinburgh research found that the salmonella released a protein -- SopB -- changing the make-up of certain cells that line the gut.

This causes a dramatic increase in cells -- called microfold or M cells.

The work, reveals how once the salmonella produces large number of these cells it can then get through into the bloodstream, causing infection.

"Bacteria have evolved sophisticated strategies to interact with and infect the host. This highlights yet another way in which microbes are able to transform cells into a type that suits their habitat," said Dr Arvind Mahajan, of The Roslin Institute at the University of Edinburgh.

The study was funded by the Biotechnology and Biological Sciences Research Council.


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Journal Reference:

  1. Amin Tahoun, Simmi Mahajan, Edith Paxton, Georg Malterer, David S. Donaldson, Dai Wang, Alwyn Tan, Trudi L. Gillespie, Marie O’Shea, Andrew J. Roe, Darren J. Shaw, David L. Gally, Andreas Lengeling, Neil A. Mabbott, Jόrgen Haas, Arvind Mahajan. Salmonella Transforms Follicle-Associated Epithelial Cells into M Cells to Promote Intestinal Invasion. Cell Host & Microbe, 2012; 12 (5): 645 DOI: 10.1016/j.chom.2012.10.009

Cite This Page:

University of Edinburgh. "Salmonella spreads by targeting cells in our gut, study shows." ScienceDaily. ScienceDaily, 11 December 2012. <www.sciencedaily.com/releases/2012/12/121211112953.htm>.
University of Edinburgh. (2012, December 11). Salmonella spreads by targeting cells in our gut, study shows. ScienceDaily. Retrieved April 21, 2014 from www.sciencedaily.com/releases/2012/12/121211112953.htm
University of Edinburgh. "Salmonella spreads by targeting cells in our gut, study shows." ScienceDaily. www.sciencedaily.com/releases/2012/12/121211112953.htm (accessed April 21, 2014).

Share This



More Health & Medicine News

Monday, April 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) — Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) — In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) — A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) — The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins