Featured Research

from universities, journals, and other organizations

Skin patches for more medicines? Some large molecules sneak through skin on their own

Date:
December 12, 2012
Source:
Albert-Ludwigs-Universität Freiburg
Summary:
Certain naturally occurring large molecules are able to sneak through the skin at a rate higher than that expected based on their size, according to a new study. The study reports a surprising finding that Avicins, plant-derived natural products with molecular weights greater than 2000, penetrate the human skin on their own.

Certain naturally occurring large molecules are able to sneak through the skin at a rate higher than that expected based on their size, according to a study published in the American scientific journal Proceedings of The National Academy of Sciences (PNAS). The study reports a surprising finding that Avicins, plant-derived natural products with molecular weights greater than 2000, penetrate the human skin on their own.

Related Articles


The study is authored by Prof. Dr. Prasad Shastri from the Institute for Macromolecular Chemistry and the cluster of excellence BIOSS Centre for Biological Signalling Studies of the University of Freiburg / Germany and his post-doctoral fellows Dr. Chris Pino and Dr. Daniel Vonwil in collaboration with Prof. Dr. Samir Mitragotri of the University of California, Santa Barbara / USA and Prof. Dr. Jordan Gutterman of the MD Anderson Cancer Center, University of Texas Houston / USA.

The researchers report that the unique structure of Avicins, which is composed of sugar residues linked to a fat-soluble core allows the molecules to gain access to the fatty component of the stratum corneum, the outermost layer of skin, which serves as a barrier for molecules to penetrate. The researchers studied penetration of various fragments of Avicins and discovered that the sugar residues of Avicins play a key role in allowing the molecules to move into and across the stratum corneum.

The findings of the study may open new opportunities in the delivery of therapeutic drugs via skin patches. Delivery of therapeutics across the skin offers many advantages, including ease of administration compared to pills and lack of pain in contrast to needle injections. However, transdermal delivery of drugs has proved challenging as the stratum corneum allows the passage of only small, oil-soluble molecules such as nicotine and estrogen. The insights gained from penetration of Avicins across the skin might provide design strategies for novel approaches to transport large molecules across the skin. Shastri and his collaborators hope to use the insights gained from this study to design drugs and proteins that can be delivered through the skin.


Story Source:

The above story is based on materials provided by Albert-Ludwigs-Universität Freiburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. J. Pino, J. U. Gutterman, D. Vonwil, S. Mitragotri, V. P. Shastri. Glycosylation facilitates transdermal transport of macromolecules. Proceedings of the National Academy of Sciences, 2012; DOI: 10.1073/pnas.1200942109

Cite This Page:

Albert-Ludwigs-Universität Freiburg. "Skin patches for more medicines? Some large molecules sneak through skin on their own." ScienceDaily. ScienceDaily, 12 December 2012. <www.sciencedaily.com/releases/2012/12/121212092640.htm>.
Albert-Ludwigs-Universität Freiburg. (2012, December 12). Skin patches for more medicines? Some large molecules sneak through skin on their own. ScienceDaily. Retrieved November 21, 2014 from www.sciencedaily.com/releases/2012/12/121212092640.htm
Albert-Ludwigs-Universität Freiburg. "Skin patches for more medicines? Some large molecules sneak through skin on their own." ScienceDaily. www.sciencedaily.com/releases/2012/12/121212092640.htm (accessed November 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) — Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) — Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com
Ebola: Life Without School in Guinea

Ebola: Life Without School in Guinea

AFP (Nov. 21, 2014) — Following the closure of schools and universities in Guinea because of the Ebola virus, students look for temporary work or gather in makeshift classrooms to catch up on their syllabus. Duration: 02:14 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins