Featured Research

from universities, journals, and other organizations

New study brings long-sought vaccines for deadly parasite closer to reality

Date:
December 13, 2012
Source:
Cell Press
Summary:
One major cause of illness from food-borne diseases is the parasite Toxoplasma gondii (T. gondii). New insights into how the immune system combats T. gondii are provided in a new study. The findings could lead to the development of long-sought vaccines to protect against T. gondii and related parasites.

This is an image of T. gondii.
Credit: Sankar Ghosh

One major cause of illness from food-borne diseases is the parasite Toxoplasma gondii (T. gondii). New insights into how the immune system combats T. gondii are provided in a study published by Cell Press Dec. 13th in the journal Immunity. The findings could lead to the development of long-sought vaccines to protect against T. gondii and related parasites.

To fight off pathogens, the immune system relies on Toll-like receptors (TLRs) -- a class of proteins that recognize microbes and activate immune responses. The important role of TLR11 in recognizing the T. gondii infection was previously demonstrated by a team led by Sankar Ghosh of Columbia University and Alan Sher of the National Institute of Allergy and Infectious Diseases. But scientists had not yet identified any TLRs -- including TLR11 -- that could promote survival in infected animals.

In the new study, Ghosh, Sher, and their collaborators focused on the previously uncharacterized TLR12 because it is closely related to TLR11 and physically interacts with that receptor, suggesting that the two might work together to mount immune responses. When they genetically engineered mice to lack TLR12, they found that immune cells could not recognize or protect against T. gondii, and these mice quickly succumbed to infection. Although both TLR11 and TLR12 activate overlapping immune responses to T. gondii in certain types of cells, TLR12 also triggers responses in a distinct set of immune cells to promote survival.

"Prior to this study, TLR12 had no known function in the immune system, and it was not known what pathogen this receptor recognized," Ghosh says. "We have demonstrated that TLR12 is essential for resistance to T. gondii in mice."

Because TLR12 also recognized another related parasite, the findings could have broad clinical implications. "By investigating how immune cells expressing TLR12 organize the immune response against T. gondii infection, we hope to identify new means of promoting protective immune responses against T. gondii and potentially other important parasite pathogens," Ghosh says.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. A.Alicia Koblansky, Dragana Jankovic, Hyunju Oh, Sara Hieny, Waradon Sungnak, Ramkumar Mathur, MatthewS. Hayden, Shizuo Akira, Alan Sher, Sankar Ghosh. Recognition of Profilin by Toll-like Receptor 12 Is Critical for Host Resistance to Toxoplasma gondii. Immunity, 2012; DOI: 10.1016/j.immuni.2012.09.016

Cite This Page:

Cell Press. "New study brings long-sought vaccines for deadly parasite closer to reality." ScienceDaily. ScienceDaily, 13 December 2012. <www.sciencedaily.com/releases/2012/12/121213121750.htm>.
Cell Press. (2012, December 13). New study brings long-sought vaccines for deadly parasite closer to reality. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2012/12/121213121750.htm
Cell Press. "New study brings long-sought vaccines for deadly parasite closer to reality." ScienceDaily. www.sciencedaily.com/releases/2012/12/121213121750.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins