Featured Research

from universities, journals, and other organizations

Chemical that fends off harm to organs: Purines fend off surgery-related damage

Date:
December 18, 2012
Source:
University of Colorado Denver
Summary:
Anesthesia is quite safe these days. But sometimes putting a patient under to fix one problem, such as heart damage, can harm a different organ, such as a kidney. Now a group of researchers has found a group of molecules -- called purines -- that fend off damage during anesthesia.

Anesthesia is quite safe these days. But sometimes putting a patient under to fix one problem, such as heart damage, can harm a different organ, such as a kidney.

Related Articles


Now a group of researchers led by Holger Eltzschig, MD, PhD, a professor of anesthesiology at the University Colorado School of Medicine, has found a group of molecules that fend off damage during anesthesia.

"This is a promising discovery," says Eltzschig, who practices at University of Colorado Hospital. "It suggests a new way to promote healing."

In an article published Dec. 12 in the New England Journal of Medicine, Eltzschig and colleagues at Harvard Medical School and Northeastern University report hopeful findings about a group of molecules called purines. Purines are basic molecular building blocks in the body -- they help produce DNA and RNA and they assist with short-term storage of energy. One variety of purine is called adenosine.

The researchers determined that generating adenosine outside of cells can help protect organs from damage. And they saw that activating adenosine receptors on the lungs, the intestine, or the heart can help protect these organs.

Eltzschig and his fellow researchers looked at adenosine and related chemical processes in cancer, lung injury, bowel inflammation and platelet function, among others.

For patients who might face surgery with anesthesia, the findings are good news.

"Increasing developments in this arena will open up several new avenues for the treatment," the article says.


Story Source:

The above story is based on materials provided by University of Colorado Denver. The original article was written by Dan Meyers. Note: Materials may be edited for content and length.


Journal Reference:

  1. Holger K. Eltzschig, Michail V. Sitkovsky, Simon C. Robson. Purinergic Signaling during Inflammation. New England Journal of Medicine, 2012; 367 (24): 2322 DOI: 10.1056/NEJMra1205750

Cite This Page:

University of Colorado Denver. "Chemical that fends off harm to organs: Purines fend off surgery-related damage." ScienceDaily. ScienceDaily, 18 December 2012. <www.sciencedaily.com/releases/2012/12/121218094310.htm>.
University of Colorado Denver. (2012, December 18). Chemical that fends off harm to organs: Purines fend off surgery-related damage. ScienceDaily. Retrieved April 2, 2015 from www.sciencedaily.com/releases/2012/12/121218094310.htm
University of Colorado Denver. "Chemical that fends off harm to organs: Purines fend off surgery-related damage." ScienceDaily. www.sciencedaily.com/releases/2012/12/121218094310.htm (accessed April 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, April 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Reuters - Innovations Video Online (Apr. 1, 2015) Israeli scientists says laser bonding of tissue allows much faster healing and less scarring. Amy Pollock has more. Video provided by Reuters
Powered by NewsLook.com
Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins