Featured Research

from universities, journals, and other organizations

Cardiovascular disease: The mechanics of prosthetic heart valves

Date:
December 20, 2012
Source:
The Agency for Science, Technology and Research (A*STAR)
Summary:
Computer simulations of blood flow through mechanical heart valves could pave the way for more individualized prosthetics.

Computer simulations of blood flow through mechanical heart valves could pave the way for more individualized prosthetics.

Related Articles


Every year, over 300,000 heart valve replacement operations are performed worldwide. Diseased valves are often replaced with mechanical heart valves (MHVs), which cannot yet be designed to suit each patient's specific needs. Complications such as blood clots can occur, which can require patients to take blood-thinning medication.

To investigate why such complications occur, Vinh-Tan Nguyen at A*STAR's Institute of High Performance Computing, Singapore, together with scientists at the National University of Singapore and institutions across the USA, have developed a new computer model to simulate the dynamics of blood flow through MHVs1.

"The current practice for heart valve replacement in patients is a one-size-fits-all approach where a patient is implanted with the best-fit valve available on the market," explains Nguyen. "The valves are well designed for general physiological conditions, but may not be suitable for each individual's particular heart condition."

The researchers focused on the blood flow dynamics in a prosthetic valve known as a bileaflet MHV. This type of MHV contains two mobile leaflets, or gates, which are held in place by hinges. The leaflets open and close in response to blood flow pressures through the valve. Little is known about the effect that the hinged leaflets have on blood dynamics, although such designs are suspected of causing blood clots.

The computer model developed by Nguyen and his team simulates pressure flows through bileaflet MHVs by representing blood vessels as a computational mesh, where calculations are performed for individual blocks of the mesh. Their crucial advance was in enabling this mesh to move and evolve in response to the leaflet movements.

The researchers validated their computer model through laboratory experiments with a full 3D reproduction of the heart's circulation system. Particle imaging equipment allowed them to visualize the fluid dynamics under different scenarios including pulsatile flow, which follows the pattern of a typical cardiac cycle.

"We obtained good agreement between our computer simulations and the experiments in terms of the magnitude and velocity of blood flow through the leaflets," states Nguyen. The researchers also found that leaflet hinges might play a vital role in clotting, because individual hinges have different tolerances that can disrupt normal blood flow and cause stress in the vein walls.

This research is a first crucial step in understanding the impact of MHVs on blood flow. "Ultimately we hope to provide doctors with a tool to evaluate blood flow dynamics and other related aspects in patients with newly implanted valves," says Nguyen.

The A*STAR-affiliated researchers contributing to this research are from the Institute of High Performance Computing.


Story Source:

The above story is based on materials provided by The Agency for Science, Technology and Research (A*STAR). Note: Materials may be edited for content and length.


Journal Reference:

  1. Vinh-Tan Nguyen, Yee Han Kuan, Po-Yu Chen, Liang Ge, Fotis Sotiropoulos, Ajit P. Yoganathan, Hwa Liang Leo. Experimentally Validated Hemodynamics Simulations of Mechanical Heart Valves in Three Dimensions. Cardiovascular Engineering and Technology, 2011; 3 (1): 88 DOI: 10.1007/s13239-011-0077-z

Cite This Page:

The Agency for Science, Technology and Research (A*STAR). "Cardiovascular disease: The mechanics of prosthetic heart valves." ScienceDaily. ScienceDaily, 20 December 2012. <www.sciencedaily.com/releases/2012/12/121220153120.htm>.
The Agency for Science, Technology and Research (A*STAR). (2012, December 20). Cardiovascular disease: The mechanics of prosthetic heart valves. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2012/12/121220153120.htm
The Agency for Science, Technology and Research (A*STAR). "Cardiovascular disease: The mechanics of prosthetic heart valves." ScienceDaily. www.sciencedaily.com/releases/2012/12/121220153120.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins