Featured Research

from universities, journals, and other organizations

Molds are able to reproduce sexually: Researchers grow penicillin-producing fungi with new properties

Date:
January 8, 2013
Source:
Ruhr-Universitaet-Bochum
Summary:
For over 100 years, it was assumed that the penicillin-producing mold fungus, Penicillium chrysogenum, only reproduced asexually through spores. Biologists have now shown for the first time that the fungus also has a sexual cycle, i.e. two "genders."

Scanning electron microscopic image of asexual conidiospores from the penicillin producer Penicillium chrysogenum
Credit: © Lehrstuhl Allgemeine und Molekulare Botanik, RUB

For over 100 years, it was assumed that the penicillin-producing mould fungus Penicillium chrysogenum only reproduced asexually through spores. An international research team led by Prof. Dr. Ulrich Kück and Julia Böhm from the Chair of General and Molecular Botany at the Ruhr-Universität has now shown for the first time that the fungus also has a sexual cycle, i.e. two "genders."

Related Articles


Through sexual reproduction of P. chrysogenum, the researchers generated fungal strains with new biotechnologically relevant properties -- such as high penicillin production without the contaminating chrysogenin. The team from Bochum, Göttingen, Nottingham (England), Kundl (Austria) and Sandoz GmbH reports in the Proceedings of the National Academy of Sciences. The article will be published in this week's Online Early Edition.

Only penicillin producer

About 100 years ago, Alexander Fleming demonstrated the formation of penicillin in Penicillium chrysogenum. To date, there is no other known producer of the antibiotic penicillin, which has an annual global market value of about six billion Euros.

Combining genes and breeding offspring with new properties

Not only animals and plants, but also many microorganisms such as fungi and algae can reproduce sexually. The advantage: the progenies possess a combination of genes from both mating partners and thus have new properties. Sexual reproduction in fungi is, however, not the rule. Most reproduce via spores which, in the case of moulds, occur as white, green or black deposits on spoiled food. These spores only bear the genes of one parent fungus. "Five years ago we already detected the existence of so-called sex genes in Penicillium chrysogenum", says Prof. Kück. Now, the researchers have discovered specific environmental conditions in which the fungus actually reproduces sexually. The decisive thing was to breed fungal strains in the dark under oxygen deprivation conditions in a nutrient medium supplemented with the vitamin biotin. The offspring exhibited new properties, both at the molecular level, as well as in their phenotypes.

Results could be applicable to other fungi

Using so-called microarray analysis, the biologists also investigated the activity of all the approximately 12,000 genes of the mould fungus. The result: the sex genes control the activity of biologically relevant genes, for example those for penicillin production. "We presume that the findings can also be applied to other fungi," says Ulrich Kück, "such as Penicillium citrinum and Aspergillus terreus that produce cholesterol-lowering statins, or Penicillium brevicompactum and Tolypocladium inflatum, which produce immunosuppressives that are used in all organ transplantations." The researchers conducted the work in the Christian Doppler Laboratory "Biotechnology of Fungi" at the Ruhr-Universität with funding from the Christian Doppler Society (Vienna).


Story Source:

The above story is based on materials provided by Ruhr-Universitaet-Bochum. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Böhm, B. Hoff, C.M. O’Gorman, S. Wolfers, V. Klix, D. Binger, I. Zadra, H. Kürnsteiner, S. Pöggeler, P.S. Dyer, U. Kück. Sexual reproduction and mating-type -- mediated strain development in the penicillin-producing fungus Penicillium chrysogenum. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1217943110

Cite This Page:

Ruhr-Universitaet-Bochum. "Molds are able to reproduce sexually: Researchers grow penicillin-producing fungi with new properties." ScienceDaily. ScienceDaily, 8 January 2013. <www.sciencedaily.com/releases/2013/01/130108084138.htm>.
Ruhr-Universitaet-Bochum. (2013, January 8). Molds are able to reproduce sexually: Researchers grow penicillin-producing fungi with new properties. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2013/01/130108084138.htm
Ruhr-Universitaet-Bochum. "Molds are able to reproduce sexually: Researchers grow penicillin-producing fungi with new properties." ScienceDaily. www.sciencedaily.com/releases/2013/01/130108084138.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) — Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
The Hottest Food Trends for 2015

The Hottest Food Trends for 2015

Buzz60 (Dec. 17, 2014) — Urbanspoon predicts whicg food trends will dominate the culinary scene in 2015. Mara Montalbano (@maramontalbano) has the story. Video provided by Buzz60
Powered by NewsLook.com
Rover Finds More Clues About Possible Life On Mars

Rover Finds More Clues About Possible Life On Mars

Newsy (Dec. 17, 2014) — NASA's Curiosity rover detected methane on Mars and organic compounds on the surface, but it doesn't quite prove there was life ... yet. Video provided by Newsy
Powered by NewsLook.com
Ivory Trade Boom Swamps Law Efforts

Ivory Trade Boom Swamps Law Efforts

Reuters - Business Video Online (Dec. 17, 2014) — Demand for ivory has claimed the lives of tens of thousands of African elephants and now a conservation report says the illegal trade is overwhelming efforts to enforce the law. Amy Pollock reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins