Featured Research

from universities, journals, and other organizations

Effects of antibiotics on gut flora analyzed

Date:
January 9, 2013
Source:
Asociación RUVID
Summary:
A new study reveals that antibiotics produce changes in the microbial and metabolic patterns of the gut. The researchers that have analyzed for the first time the bacteria, genes, enzymes and molecules that form the gut microbiota of patients treated with antibiotics.

A study co-led by researchers at the Universitat de València reveals that antibiotics produce changes in the microbial and metabolic patterns of the gut. The researchers that have analyzed for the first time the bacteria, genes, enzymes and molecules that form the gut microbiota of patients treated with antibiotics publish the results of their study in the online edition of the journal Gut.

Related Articles


In the gut live one trillion bacteria, which are known as microbiota or gut flora, and that have co-evolved in symbiosis with humans. According to this study, treatment with antibiotics can alter this symbiosis from early stages of the treatment. "Although some of the changes are oscillatory and can be reversed at the end of the treatment, others seem irreversible," says one of the coordinators of the study, Andrés Moya, who works at Cavanilles Institute of Biodiversity and Evolutionary Biology of the Science Park of the Universitat de València.

The research, which has had the collaboration of the CSIC, the Centre Superior d'Investigació en Salut Pública (CSISP) (Centre for Advanced Research in Public Health), the University CEU San Pablo and the Centre d'Investigació Biomèdica en Xarxa en Epidemiologia i Salut Pública (CIBEResp) (Centre for Biomedical Research in Epidemiology and Public Health), has compared stool samples of a patient taken before and after the treatment.

Changes in gut bacteria

The biodiversity of the bacteria that form the gut microbiota, according to the results, decreases during the treatment to the point of reaching its minimum 11 days after the beginning. However, at the end of the treatment, the situation is reversed and the patient presents a bacterial population similar to the first.

Although the research "shows for the first time that gut bacteria presents a lower capacity to produce proteins, as well as deficiencies in key activities, during and after the treatment," explains Moya. Specifically, the study suggests that the gut microbiota shows less capacity to absorb iron, digest certain foods and produce essential molecules for the organism.

The research also shows that less abundant bacteria in the gut flora, but little active at the beginning of the treatment, at the end they became active and they may play an important role in the gut as a consequence of the antibiotics, according to Manuel Ferrer, researcher of the CSIC. "These bacteria could be responsible for improving the interconnection between the liver and colon and of the production of essential molecules such as bile acids, hormones and cholesterol derivatives," say the researchers.

"Personalized therapies and interventions can only be reached through a comprehensive and detailed analysis of the different antibiotics and people from different geographical origin, age or state of health," concludes Moya.


Story Source:

The above story is based on materials provided by Asociación RUVID. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. E. Perez-Cobas, M. J. Gosalbes, A. Friedrichs, H. Knecht, A. Artacho, K. Eismann, W. Otto, D. Rojo, R. Bargiela, M. von Bergen, S. C. Neulinger, C. Daumer, F.-A. Heinsen, A. Latorre, C. Barbas, J. Seifert, V. M. dos Santos, S. J. Ott, M. Ferrer, A. Moya. Gut microbiota disturbance during antibiotic therapy: a multi-omic approach. Gut, 2012; DOI: 10.1136/gutjnl-2012-303184

Cite This Page:

Asociación RUVID. "Effects of antibiotics on gut flora analyzed." ScienceDaily. ScienceDaily, 9 January 2013. <www.sciencedaily.com/releases/2013/01/130109081145.htm>.
Asociación RUVID. (2013, January 9). Effects of antibiotics on gut flora analyzed. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2013/01/130109081145.htm
Asociación RUVID. "Effects of antibiotics on gut flora analyzed." ScienceDaily. www.sciencedaily.com/releases/2013/01/130109081145.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Lioness Has Rare Five-Cub Litter

Raw: Lioness Has Rare Five-Cub Litter

AP (Mar. 27, 2015) — A lioness in Pakistan has given birth to five cubs, twice the usual size of a litter. Queen gave birth to two other cubs just nine months ago. (March 27) Video provided by AP
Powered by NewsLook.com
Jockey Motion Tracking Reveals Racing Prowess

Jockey Motion Tracking Reveals Racing Prowess

Reuters - Innovations Video Online (Mar. 26, 2015) — Using motion tracking technology, researchers from the Royal Veterinary College (RVC) are trying to establish an optimum horse riding style to train junior jockeys, as well as enhance safety, health and well-being of both racehorses and jockeys. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Bear Cubs Tumble for the Media

Bear Cubs Tumble for the Media

Reuters - Light News Video Online (Mar. 26, 2015) — Two Andean bear cubs are unveiled at the U.S. National Zoo in Washington, D.C. Alicia Powell reports. Video provided by Reuters
Powered by NewsLook.com
Botswana Talks to End Illegal Wildlife Trade

Botswana Talks to End Illegal Wildlife Trade

AFP (Mar. 25, 2015) — Experts are gathering in Botswana to try to end the illegal wildlife trade that is decimating populations of elephants, rhinos and other threatened species. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins