Featured Research

from universities, journals, and other organizations

Schmallenberg virus genome engineered to understand how to reduce disease caused by the virus

Date:
January 10, 2013
Source:
Public Library of Science
Summary:
Researchers have developed methods to synthesize and change the genome of Schmallenberg virus (SBV). SBV is a recently discovered pathogen of livestock such as cattle, sheep and goats. The researchers have laid bare important ways by which this virus causes disease.

Scientists engineer the Schmallenberg virus genome to understand how to reduce disease caused by the virus.

Related Articles


Researchers from the MRC Centre for Virus Research at the University of Glasgow in Scotland have developed methods to synthesize and change the genome of Schmallenberg virus (SBV). SBV is a recently discovered pathogen of livestock such as cattle, sheep and goats. The researchers have laid bare important ways by which this virus causes disease. The full report about the study publishes on January 10 in the Open Access journal, PLOS Pathogens.

SBV is of great concern because it causes stillbirths, abortions and fetal defects in pregnant cows and ewes. It has spread rapidly throughout Europe since its discovery in Germany less than eighteen months ago (in October 2011).

The new study describes researchers' use of molecular biological methods to design and assemble the viral "genome" completely in a test tube in a form that can be easily introduced and replicated in cultured cells. From these cells the researchers recovered virus with identical infection properties to the "natural" SBV. This approach, known as 'reverse genetics', allowed them to control the viral genome and identify a gene (called NSs) involved in protecting the virus against the immune response of infected animals. The researchers made viruses missing the NSs gene and found they made mice in the laboratory less sick than viruses containing the NSs gene. The researchers also discovered that SBV rapidly grows in the brain and spinal cord of aborted lambs and calves. The virus prefers to infect cells called neurons, which explains why it infects and damages the brain. This also results in muscular defects such as abnormally flexed legs often seen in stillborn animals when virus is transmitted from an SBV infected mother to the calves or lambs in the uterus during pregnancy.

Scottish researchers, led by Massimo Palmarini and Alain Kohl, suggest that the ability to engineer and control the SBV genome will allow the future development of new vaccines for this virus that is of great concern to European farmers. This work was conducted in collaboration with scientists in Italy at the Istituto G. Caporale and Germany (University of Veterinary Medicine in Hannover and the Friedrich Loeffler Institut).


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mariana Varela, Esther Schnettler, Marco Caporale, Claudio Murgia, Gerald Barry, Melanie McFarlane, Eva McGregor, Ilaria M. Piras, Andrew Shaw, Catherine Lamm, Anna Janowicz, Martin Beer, Mandy Glass, Vanessa Herder, Kerstin Hahn, Wolfgang Baumgδrtner, Alain Kohl, Massimo Palmarini. Schmallenberg Virus Pathogenesis, Tropism and Interaction with the Innate Immune System of the Host. PLoS Pathogens, 2013; 9 (1): e1003133 DOI: 10.1371/journal.ppat.1003133

Cite This Page:

Public Library of Science. "Schmallenberg virus genome engineered to understand how to reduce disease caused by the virus." ScienceDaily. ScienceDaily, 10 January 2013. <www.sciencedaily.com/releases/2013/01/130110212325.htm>.
Public Library of Science. (2013, January 10). Schmallenberg virus genome engineered to understand how to reduce disease caused by the virus. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2013/01/130110212325.htm
Public Library of Science. "Schmallenberg virus genome engineered to understand how to reduce disease caused by the virus." ScienceDaily. www.sciencedaily.com/releases/2013/01/130110212325.htm (accessed October 24, 2014).

Share This



More Plants & Animals News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Reuters - Innovations Video Online (Oct. 24, 2014) — Miniature deep sea animals discovered off the Australian coast almost three decades ago are puzzling scientists, who say the organisms have proved impossible to categorise. Academics at the Natural History of Denmark have appealed to the world scientific community for help, saying that further information on Dendrogramma enigmatica and Dendrogramma discoides could answer key evolutionary questions. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Black Bear Cub Goes Sunday Shopping

Black Bear Cub Goes Sunday Shopping

Reuters - Light News Video Online (Oct. 23, 2014) — Price check on honey? Bear cub startles Oregon drugstore shoppers. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Dances With Wolves in China's Wild West

Dances With Wolves in China's Wild West

AFP (Oct. 23, 2014) — One man is on a mission to boost the population of wolves in China's violence-wracked far west. The animal - symbol of the Uighur minority there - is under threat with a massive human resettlement program in the region. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) — Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins