Featured Research

from universities, journals, and other organizations

Fetal exposure to tributyltin linked to obesity

Date:
January 24, 2013
Source:
University of California - Irvine
Summary:
Exposing pregnant mice to low doses of the chemical tributyltin -- which was used in marine antifouling paints and is used as an antifungal agent in some paints, certain plastics and a variety of consumer products -- can lead to obesity for multiple generations without subsequent exposure, a new study has found.

Exposing pregnant mice to low doses of the chemical tributyltin (TBT) -- which was used in marine antifouling paints and is used as an antifungal agent in some paints, certain plastics and a variety of consumer products -- can lead to obesity for multiple generations without subsequent exposure, a UC Irvine study has found.

After exposing pregnant mice to TBT at low concentrations, similar to those found in the environment and in humans, researchers observed increased body fat, liver fat and fat-specific gene expression in liver and stem cells in mouse "children," "grandchildren" and "great-grandchildren." The "children" were exposed as embryos, while the "grandchildren" may have been exposed as germ cells within the "children." The "great-grandchildren" had never been exposed to TBT. Such effects without exposure are termed transgenerational and thought to be permanently transmitted to future generations.

These findings demonstrate that early-life exposure to endocrine-disrupting compounds such as TBT can have permanent effects on fat accumulation, gene expression and stem cell programming without further exposure, said study leader Professor Bruce Blumberg with the UC Irvine Departments of Developmental & Cell Biology, Pharmaceutical Sciences and Biomedical Engineering.

The study appeared online Jan. 15 in Environmental Health Perspectives, a publication of the National Institute for Environmental Health Sciences.

Human exposure to TBT and related organotins can occur in a variety of ways. TBT contaminates particles derived from such products as shower curtains, vinyl flooring, carpet fibers, polyurethane foams, mold-resistant paints and other consumer products, where it is used as an antifungal agent. As a result, noteworthy levels of TBT have been reported in house dust, which may be particularly relevant for young children who can spend significant time on floors and carpets.

Although TBT is now largely banned for use in marine hull paints, it remains pervasive in the environment, and people can be exposed by ingesting TBT-contaminated seafood. Organotins may also leach into liquids that come into contact with organotin-containing plastic pipes, containers and packaging materials.

Blumberg categorizes TBT as an obesogen, a class of chemicals that promote obesity by increasing the number of fat cells and the storage of fat in existing cells or by altering metabolic regulation of appetite and satiety. He and his colleagues identified TBT as an obesogen in a 2006 publication and showed in 2010 that TBT acts in part by modifying the fate of mesenchymal stem cells during development, predisposing them to become fat cells.


Story Source:

The above story is based on materials provided by University of California - Irvine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Raquel Chamorro-Garcνa, Margaret Sahu, Rachelle J. Abbey, Jhyme Laude, Nhieu Pham, Bruce Blumberg. Transgenerational Inheritance of Increased Fat Depot Size, Stem Cell Reprogramming, and Hepatic Steatosis Elicited by Prenatal Obesogen Tributyltin in Mice. Environmental Health Perspectives, 2013; DOI: 10.1289/ehp.1205701

Cite This Page:

University of California - Irvine. "Fetal exposure to tributyltin linked to obesity." ScienceDaily. ScienceDaily, 24 January 2013. <www.sciencedaily.com/releases/2013/01/130124163412.htm>.
University of California - Irvine. (2013, January 24). Fetal exposure to tributyltin linked to obesity. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2013/01/130124163412.htm
University of California - Irvine. "Fetal exposure to tributyltin linked to obesity." ScienceDaily. www.sciencedaily.com/releases/2013/01/130124163412.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) — A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) — Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) — California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
New Drug Could Reduce Cardiovascular Deaths

New Drug Could Reduce Cardiovascular Deaths

Newsy (Aug. 30, 2014) — The new drug from Novartis could reduce cardiovascular deaths by 20 percent compared to other similar drugs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins