Featured Research

from universities, journals, and other organizations

Scientists identify four mechanisms that contribute to gastric cancers

Date:
January 28, 2013
Source:
Agency for Science, Technology and Research (A*STAR), Singapore
Summary:
Scientists have discovered four processes by which gastric cancer is formed. This is extremely important since gastric cancer is the second most common cause of cancer deaths worldwide, claiming almost 750,000 lives annually, 60 percent of which are Asians.

Scientists at A*STAR's Genome Institute of Singapore (GIS) headed a study that discovered four processes by which gastric cancer is formed. This is extremely important since gastric cancer is the second most common cause of cancer deaths worldwide, claiming almost 750,000 lives annually, 60% of which are Asians.

Related Articles


Using what is known as next-generation sequencing technologies, GIS scientists were able to provide a comprehensive view of the gastric cancer genome, characterizing micro- and macro-scale mutations. This led to the identification of four distinct processes that cause mutations in gastric cancer. One of these was found to have a targeted impact on genes and is potentially triggered by bacterial infection. The other processes were found to have impact throughout the genome, and included oxidative damage processes and the failure of DNA proof-reading mechanisms.

The discovery of the mutative actions of these processes provides essential clues to the formation of gastric cancers, paving the way for diagnostics and targeted therapy.

The findings were published online in the December 2012 issue of Genome Biology.

First author and GIS Principal Investigator Dr Niranjan Nagarajan said, "Cancers are constantly evolving, and therefore understanding how they do so is important for finding new treatments. Mutational processes in cancer had not previously been shown to have a targeted impact on the genome and on genes. With this study, we show evidence of this for the very first time. This is truly exciting since it moves us a critical step towards understanding and finding a cure for gastric cancer."

Co-author and GIS Principal Investigator Dr Patrick Tan said, "This is the first time gastric cancers have been analyzed at the whole genome level. This work further showcases the reputation of Singapore as a world-leader in gastric cancer research."

"Our study demonstrates that sequencing gastric tumours not only allows the identification of mutations in the human genome but also reveals micro-organisms and their pathogenic gene content," added Dr Axel Hillmer, GIS Principal Investigator.

GIS Executive Director, Prof Ng Huck Hui said, ""This is a very exciting study that probed into the genomic signature of gastric cancers. Through the analysis of somatic mutations occurring in gastric cancers, this team has identified several interesting genes which have profound implications in cancers."


Story Source:

The above story is based on materials provided by Agency for Science, Technology and Research (A*STAR), Singapore. Note: Materials may be edited for content and length.


Journal Reference:

  1. Niranjan Nagarajan, Denis Bertrand, Axel M. Hillmer, Zhi Jiang Zang, Fei Yao, Pierre-Etienne Jacques, Audrey S.M. Teo, Ioanna Cutcutache, Zhenshui Zhang, Wah Heng Lee, Yee Yen Sia, Song Gao, Pramila N. Ariyaratne, Andrea Ho, Xing Yi Woo, Lavanya Veeravali, Choon Kiat Ong, Niantao Deng, Kartiki V. Desai, Chiea Chuen Khor, Martin L. Hibberd, Atif Shahab, Jaideepraj Rao, Mengchu Wu, Ming Teh, Feng Zhu, Sze Yung Chin, Brendan Pang, Jimmy B.Y. So, Guillaume Bourque, Richie Soong, Wing-Kin Sung, Bin Tean Teh, Steven Rozen, Xiaoan Ruan, Khay Guan Yeoh, Patrick B.O. Tan, Yijun Ruan. Whole-genome reconstruction and mutational signatures in gastric cancer. Genome Biology, 2012; 13 (12): R115 DOI: 10.1186/gb-2012-13-12-r115

Cite This Page:

Agency for Science, Technology and Research (A*STAR), Singapore. "Scientists identify four mechanisms that contribute to gastric cancers." ScienceDaily. ScienceDaily, 28 January 2013. <www.sciencedaily.com/releases/2013/01/130128104743.htm>.
Agency for Science, Technology and Research (A*STAR), Singapore. (2013, January 28). Scientists identify four mechanisms that contribute to gastric cancers. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2013/01/130128104743.htm
Agency for Science, Technology and Research (A*STAR), Singapore. "Scientists identify four mechanisms that contribute to gastric cancers." ScienceDaily. www.sciencedaily.com/releases/2013/01/130128104743.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

    Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins