Featured Research

from universities, journals, and other organizations

Tracking the evolution of antibiotic resistance

Date:
February 1, 2013
Source:
Biophysical Society
Summary:
An automated device is yielding a new understanding of how antibiotic resistance evolves at the genetic level.

With the discovery of antibiotics, medicine acquired power on a scale never before possible to protect health, save lives, and reduce suffering caused by certain bacteria. But the power of antibiotics is now under siege because some virulent infections no longer respond to antibiotic drugs.

Related Articles


This antibiotic resistance is an urgent public health threat that a team of researchers from Sabanci University in Istanbul, Turkey, and Harvard Medical School and Harvard University in Cambridge, Mass., aim to stop. Their approach is based on an automated device they created that yields a new understanding of how antibiotic resistance evolves at the genetic level. The team will present its work at the 57th Annual Meeting of the Biophysical Society (BPS), held Feb. 2-6, 2013, in Philadelphia, Pa.

Called the "morbidostat," the device grows bacteria in various concentrations of antibiotic. This enabled researchers to identify the concentrations at which the antibiotics stopped working and the bacteria became resistant to therapy. Next, they targeted key genes involved in creating the drug-resistant states. Their approach documented real-time changes in genes that gave bacteria an advantage in evolving to "outwit" antibiotics.

Knowledge at the gene level can be applied to the molecular design of the next generation of bacteria-killing antibiotics.

"Morbidostat is designed to evolve bacteria in conditions comparable with clinical settings," explains Erdal Toprak of Sabanci University. "Combined with next generation genome sequencing technologies, it is possible to follow the evolution of resistance in real time and identify resistance-conferring genetic changes that accumulate in the bacterial genome."

Data show an unusual survival profile of the common bacteria they used, Escherichia coli. "We identified striking features in the evolution of resistance to the antibiotic trimethoprim," Toprak says. It was these unusual features that helped them isolate the gene involved in conferring antibiotic resistance through multiple mutations.

The team's next steps will involve determining how this genetic information might one day be applied to drug design to develop new antibiotic therapies.


Story Source:

The above story is based on materials provided by Biophysical Society. Note: Materials may be edited for content and length.


Cite This Page:

Biophysical Society. "Tracking the evolution of antibiotic resistance." ScienceDaily. ScienceDaily, 1 February 2013. <www.sciencedaily.com/releases/2013/02/130201095949.htm>.
Biophysical Society. (2013, February 1). Tracking the evolution of antibiotic resistance. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2013/02/130201095949.htm
Biophysical Society. "Tracking the evolution of antibiotic resistance." ScienceDaily. www.sciencedaily.com/releases/2013/02/130201095949.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Anglerfish Rarely Seen In Its Habitat Will Haunt You

Anglerfish Rarely Seen In Its Habitat Will Haunt You

Newsy (Nov. 22, 2014) For the first time Monterey Bay Aquarium recorded a video of the elusive, creepy and rarely seen anglerfish. Video provided by Newsy
Powered by NewsLook.com
Birds Around the World Take Flight

Birds Around the World Take Flight

Reuters - Light News Video Online (Nov. 22, 2014) An imperial eagle equipped with a camera spreads its wings over London. It's just one of the many birds making headlines in this week's "animal roundup". Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Baby Okapi Born at Houston Zoo

Raw: Baby Okapi Born at Houston Zoo

AP (Nov. 20, 2014) The Houston Zoo released video of a male baby okapi. Okapis, also known as the "forest giraffe", are native to the Democratic Republic of the Congo in Central Africa. Video is mute from source. (Nov. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins