Featured Research

from universities, journals, and other organizations

Rheumatism: Scientists improve arthritis treatments

Date:
February 14, 2013
Source:
Charité - Universitätsmedizin Berlin
Summary:
Scientists have presented a new therapy approach for the treatment of rheumatoid arthritis (RA), a chronic form of joint inflammation. The new therapy study was especially directed at patients who showed no adequate response to conventional treatment with tumor-necrosis-factor directed reagents (anti TNF). The new approach represents a combined form of treatment with the medication Methotrexat and Tofacitinib.

Together with colleagues from the international rheumatic diseases research community, scientists of the Charité -- Universitätsmedizin Berlin have presented a new therapy approach for the treatment of rheumatoid arthritis (RA), a chronic form of joint inflammation. The new therapy study was especially directed at patients who showed no adequate response to conventional treatment with tumor-necrosis-factor directed reagents (anti TNF). The new approach represents a combined form of treatment with the medication Methotrexat and Tofacitinib.

The results were recently published in the medical journal The Lancet.

Rheumatoid arthritis is a widespread autoimmune disorder where long lasting inflammatory processes cause strong pain and gradually destroy the joints of the patients affected. In the majority of RA patients, there is an enhanced level of a certain cytokine in the body, the so-called tumor-necrosis-factor (TNF). This mediator is formed by immune cells, and is, among other factors responsible for the painful symptoms. The treatment with anti-TNF agents neutralises the signal effects of TNF and thus alleviates the suffering of those affected. However, should such a treatment show no effect, then alternative treatment methods have to be applied. During the course of a six month study, 399 patients in 13 countries participated, who were suffering from a moderate to severe form of rheumatoid arthritis. They were all treated with a combination of Methotrexat, a standard drug for the treatment of RA and Tofacitinib, a new type of medication which can be administered orally as a tablet. Tofacitinib is a kinase inhibitor, which inhibits special enzymes which are involved in the inflammatory reactions in patients with rheumatoid arthritis. When the so-called Janus kinases are inhibited, painful immune reactions are reduced.

This current study has shown that the combination of Methotrexat and Tofacitinib has ia high degree of efficacy in the treatment of RA, even in patients, who failed to react to standard treatment of severe cases with anti TNF agents. After half a year, the additional administration of the new medication led to an improvement in the initial symptoms in more than half of the patients. This meant that conditions of painful joint inflammation can now be efficiently treated with this drug, even in cases that had been refractory to anti-TNF treatment.

Prof. Burmester, the Principal Investigator of the Study views the results as a highly effective alternative in the treatment of rheumatoid arthritis. As a next step, long-term examinations are to be initiated, for the purpose of recording the effectiveness and the compatibility as well as any possible risks of the new combination therapy.


Story Source:

The above story is based on materials provided by Charité - Universitätsmedizin Berlin. Note: Materials may be edited for content and length.


Journal Reference:

  1. Gerd R Burmester, Ricardo Blanco, Christina Charles-Schoeman, Jürgen Wollenhaupt, Cristiano Zerbini, Birgitta Benda, David Gruben, Gene Wallenstein, Sriram Krishnaswami, Samuel H Zwillich, Tamas Koncz, Koshika Soma, John Bradley, Charles Mebus. Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial. The Lancet, 2013; 381 (9865): 451 DOI: 10.1016/S0140-6736(12)61424-X

Cite This Page:

Charité - Universitätsmedizin Berlin. "Rheumatism: Scientists improve arthritis treatments." ScienceDaily. ScienceDaily, 14 February 2013. <www.sciencedaily.com/releases/2013/02/130214075445.htm>.
Charité - Universitätsmedizin Berlin. (2013, February 14). Rheumatism: Scientists improve arthritis treatments. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2013/02/130214075445.htm
Charité - Universitätsmedizin Berlin. "Rheumatism: Scientists improve arthritis treatments." ScienceDaily. www.sciencedaily.com/releases/2013/02/130214075445.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) — The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) — A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) — The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) — The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins