Featured Research

from universities, journals, and other organizations

Pancreatitis doubles for those taking new class of diabetes drugs, scientists say

Date:
February 21, 2013
Source:
Johns Hopkins Medicine
Summary:
People who take the newest class of diabetes drugs to control blood sugar are twice as likely as those on other forms of sugar-control medication to be hospitalized with pancreatitis, researchers report.

People who take the newest class of diabetes drugs to control blood sugar are twice as likely as those on other forms of sugar-control medication to be hospitalized with pancreatitis, Johns Hopkins researchers report.

In an article published online in JAMA Internal Medicine, the scientists say the new drugs -- glucagon-like peptide-1-based therapies (GLP-1) -- are associated with an increased risk of hospitalization for acute pancreatitis. The agents sitagliptin and exenatide -- generic names for the drugs sold under the brand names Januvia and Byetta -- appear to contribute to the formation of lesions in the pancreas and the proliferation of ducts in the organ, resulting in wellsprings of inflammation.

Physicians and regulators have been aware that pancreatitis could be a side effect of GLP-1 therapies, a risk that emerged in animal studies and reports to the U.S. Food and Drug Administration. But the Johns Hopkins investigators say their study is the first to accurately measure the strength of this risk in analyses that accounted for other pancreatitis risk factors, such as gallstones, obesity and heavy alcohol use.

"These agents are used by millions of Americans with diabetes. These new diabetes drugs are very effective in lowering blood glucose. However, important safety findings may not have been fully explored and some side effects such as acute pancreatitis don't appear until widespread use after approval," says study leader Sonal Singh, M.D., M.P.H., an assistant professor in the Division of General Internal Medicine at the Johns Hopkins University School of Medicine.

Patients should be alert to symptoms of pancreatitis -- nausea, vomiting that won't stop, abdominal pain -- and seek treatment immediately if any symptoms noted on the drug label occur.

Pancreatitis is marked by inflammation of the pancreas, the organ that releases such hormones as insulin and glucagon, as well as enzymes that help digest food. A painful condition, pancreatitis can be dangerous if left untreated.

Singh and his colleagues based their findings on analysis of data from seven BlueCross BlueShield health insurance plans. They first identified 1,269 beneficiaries with type 2 diabetes who filled at least one prescription for any drug to treat the disease between 2005 and 2008. After matching them with 1,269 type 2 diabetics who had not, and controlling for the other known pancreatitis risk factors, the researchers found that people who took one of the GLP-1 therapies were twice as likely to be hospitalized with pancreatitis within 60 days of first taking the drugs as those who had taken a different medication.

In a healthy person, the pancreas releases insulin to help the body store and use sugar from food. Diabetes occurs when the pancreas does not produce the right amount of insulin or the body does not respond appropriately to the hormone. When there isn't enough insulin, or the insulin is not used as it should be, glucose (sugar) can't get into the body's cells and builds up in the bloodstream instead. Because of the role of the pancreas in diabetes, people with diabetes are already at an increased risk for pancreatitis.

This research was supported by the Johns Hopkins Clinical Research Scholars Program, the National Institutes of Health's National Center for Research Resources (1KL2RR025006-03) and the NIH Roadmap for Medical Research.

Other Johns Hopkins researchers involved in the study include Hsien-Yen Chang, Ph.D.; Thomas M. Richards, M.S.; Jonathan P. Weiner, Dr.Ph.; Jeanne M. Clark, M.D., M.P.H.; and Jodi B. Segal, M.D., M.P.H.


Story Source:

The above story is based on materials provided by Johns Hopkins Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medicine. "Pancreatitis doubles for those taking new class of diabetes drugs, scientists say." ScienceDaily. ScienceDaily, 21 February 2013. <www.sciencedaily.com/releases/2013/02/130221141104.htm>.
Johns Hopkins Medicine. (2013, February 21). Pancreatitis doubles for those taking new class of diabetes drugs, scientists say. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2013/02/130221141104.htm
Johns Hopkins Medicine. "Pancreatitis doubles for those taking new class of diabetes drugs, scientists say." ScienceDaily. www.sciencedaily.com/releases/2013/02/130221141104.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins