Featured Research

from universities, journals, and other organizations

How chronic stress accelerates Alzheimer’s disease

Date:
March 14, 2013
Source:
Ume universitet
Summary:
Why does chronic stress lead to increased risk for dementia? The answer may lie in the elevation of stress steroids that is seen in the brain during stress, a researcher suggests.

Why does chronic stress lead to increased risk for dementia? The answer may lie in the elevation of stress steroids that is seen in the brain during stress, Sara K. Bengtsson suggests in the thesis she is defending at Ume University in Sweden on March 22nd.

These stress steroids can inhibit the general brain activity. Allopregnanolon is one of them, and the doctoral thesis shows that chronically elevated levels of allopregnanolone accelerated the disease development in two transgenic Alzheimer disease models. The Alzheimer mice responded with impaired learning and memory. They had also increased brain levels of beta-amyloids, i.e. the proteins that form plaques in Alzheimer's disease.

The thesis also demonstrates that high levels of beta-amyloids corresponded to dysfunction among brain synapses. This was seen after a period of chronically elevated levels of allopregnanolon, but not after placebo treatment. The effects were identified early in the disease development when the animals normally have intact memory function. A similar acceleration of AD in humans could mean the difference between living self-sufficiently at home and living with requirements of professional care.

Sara K. Bengtsson was born in Malm, Sweden, and completed her pre-university graduation in Ystad. Professionally, Sara K. Bengtsson has worked in various fields and in 2008 she completed her Master's degree in medicine with a major in biomedicine at Ume University, Sweden, where she now is a postgraduate student at the Department of Clinical Sciences, division of Obstetrics and Gynecology.

On Friday, March 22nd, Sara K. Bengtsson, Department of Clinical Sciences, Ume University, is publicly defending her thesis with the title Stress steroids as accelerators of Alzheimer's disease. Effects of chronically elevated levels of allopregnanolone in transgenic AD models.

Read the thesis or abstract at: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-66572


Story Source:

The above story is based on materials provided by Ume universitet. Note: Materials may be edited for content and length.


Cite This Page:

Ume universitet. "How chronic stress accelerates Alzheimer’s disease." ScienceDaily. ScienceDaily, 14 March 2013. <www.sciencedaily.com/releases/2013/03/130314085049.htm>.
Ume universitet. (2013, March 14). How chronic stress accelerates Alzheimer’s disease. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2013/03/130314085049.htm
Ume universitet. "How chronic stress accelerates Alzheimer’s disease." ScienceDaily. www.sciencedaily.com/releases/2013/03/130314085049.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins