Featured Research

from universities, journals, and other organizations

How chronic stress accelerates Alzheimer’s disease

Date:
March 14, 2013
Source:
Ume universitet
Summary:
Why does chronic stress lead to increased risk for dementia? The answer may lie in the elevation of stress steroids that is seen in the brain during stress, a researcher suggests.

Why does chronic stress lead to increased risk for dementia? The answer may lie in the elevation of stress steroids that is seen in the brain during stress, Sara K. Bengtsson suggests in the thesis she is defending at Ume University in Sweden on March 22nd.

Related Articles


These stress steroids can inhibit the general brain activity. Allopregnanolon is one of them, and the doctoral thesis shows that chronically elevated levels of allopregnanolone accelerated the disease development in two transgenic Alzheimer disease models. The Alzheimer mice responded with impaired learning and memory. They had also increased brain levels of beta-amyloids, i.e. the proteins that form plaques in Alzheimer's disease.

The thesis also demonstrates that high levels of beta-amyloids corresponded to dysfunction among brain synapses. This was seen after a period of chronically elevated levels of allopregnanolon, but not after placebo treatment. The effects were identified early in the disease development when the animals normally have intact memory function. A similar acceleration of AD in humans could mean the difference between living self-sufficiently at home and living with requirements of professional care.

Sara K. Bengtsson was born in Malm, Sweden, and completed her pre-university graduation in Ystad. Professionally, Sara K. Bengtsson has worked in various fields and in 2008 she completed her Master's degree in medicine with a major in biomedicine at Ume University, Sweden, where she now is a postgraduate student at the Department of Clinical Sciences, division of Obstetrics and Gynecology.

On Friday, March 22nd, Sara K. Bengtsson, Department of Clinical Sciences, Ume University, is publicly defending her thesis with the title Stress steroids as accelerators of Alzheimer's disease. Effects of chronically elevated levels of allopregnanolone in transgenic AD models.

Read the thesis or abstract at: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-66572


Story Source:

The above story is based on materials provided by Ume universitet. Note: Materials may be edited for content and length.


Cite This Page:

Ume universitet. "How chronic stress accelerates Alzheimer’s disease." ScienceDaily. ScienceDaily, 14 March 2013. <www.sciencedaily.com/releases/2013/03/130314085049.htm>.
Ume universitet. (2013, March 14). How chronic stress accelerates Alzheimer’s disease. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2013/03/130314085049.htm
Ume universitet. "How chronic stress accelerates Alzheimer’s disease." ScienceDaily. www.sciencedaily.com/releases/2013/03/130314085049.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Reuters - Innovations Video Online (Apr. 1, 2015) Israeli scientists says laser bonding of tissue allows much faster healing and less scarring. Amy Pollock has more. Video provided by Reuters
Powered by NewsLook.com
Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins