Featured Research

from universities, journals, and other organizations

Drug-resistant MRSA bacteria: Here to stay in both hospital and community

Date:
March 15, 2013
Source:
Princeton University
Summary:
The drug-resistant bac­te­ria known as MRSA, once con­fined to hos­pi­tals but now wide­spread in com­mu­ni­ties, will likely con­tinue to exist in both set­tings as sep­a­rate strains, accord­ing to a new study.

A col­orized scan­ning elec­tron micro­graph of a white blood cell eat­ing an antibi­otic resis­tant strain of Staphy­lo­coc­cus aureus bac­te­ria, com­monly known as MRSA.
Credit: National Insti­tute of Allergy and Infec­tious Dis­eases (NIAID)

The drug-resistant bac­te­ria known as MRSA, once con­fined to hos­pi­tals but now wide­spread in com­mu­ni­ties, will likely con­tinue to exist in both set­tings as sep­a­rate strains, accord­ing to a new study.

The pre­dic­tion that both strains will coex­ist is reas­sur­ing because pre­vi­ous pro­jec­tions indi­cated that the more inva­sive and fast-growing com­mu­nity strains would over­take and elim­i­nate hos­pi­tal strains, pos­si­bly pos­ing a threat to pub­lic health.

Researchers at Prince­ton Uni­ver­sity used math­e­mat­i­cal mod­els to explore what will hap­pen to com­mu­nity and hos­pi­tal MRSA strains, which dif­fer genet­i­cally. Orig­i­nally MRSA, which is short for methicillin-resistant Staphy­lo­coc­cus aureus, was con­fined to hos­pi­tals. How­ever, community-associated strains emerged in the past decade and can spread widely from per­son to per­son in schools, ath­letic facil­i­ties and homes.

Both com­mu­nity and hos­pi­tal strains cause dis­eases rang­ing from skin and soft-tissue infec­tions to pneu­mo­nia and sep­ticemia. Hos­pi­tal MRSA is resis­tant to numer­ous antibi­otics and is very dif­fi­cult to treat, while com­mu­nity MRSA is resis­tant to fewer antibiotics.

The new study found that these dif­fer­ences in antibi­otic resis­tance, com­bined with more aggres­sive antibi­otic usage pat­terns in hos­pi­tals ver­sus the com­mu­nity set­ting, over time will per­mit hos­pi­tal strains to sur­vive despite the com­pe­ti­tion from com­mu­nity strains. Hospital-based antibi­otic usage is likely to suc­cess­fully treat patients infected with com­mu­nity strains, pre­vent­ing the new­comer strains from spread­ing to new patients and gain­ing the foothold they need to out-compete the hos­pi­tal strains.

The researchers made their pre­dic­tions by using math­e­mat­i­cal mod­els of MRSA trans­mis­sion that take into account data on drug-usage, resis­tance pro­files, person-to-person con­tact, and patient age.

Pub­lished Feb­ru­ary 28 in the jour­nal PLOS Pathogens, the study was con­ducted by post­doc­toral researcher Roger Kouyos, now a scholar at the Uni­ver­sity of Zurich, and Eili Klein, a grad­u­ate stu­dent who is now an assis­tant pro­fes­sor in the Johns Hop­kins School of Med­i­cine. They con­ducted the work under the advise­ment of Bryan Gren­fell, Princeton's Kathryn Briger and Sarah Fen­ton Pro­fes­sor of Ecol­ogy and Evo­lu­tion­ary Biol­ogy and Pub­lic Affairs at Princeton's Woodrow Wil­son School of Inter­na­tional and Pub­lic Affairs.


Story Source:

The above story is based on materials provided by Princeton University. The original article was written by Catherine Zandonella. Note: Materials may be edited for content and length.


Journal Reference:

  1. Roger Kouyos, Eili Klein, Bryan Grenfell. Hospital-Community Interactions Foster Coexistence between Methicillin-Resistant Strains of Staphylococcus aureus. PLoS Pathogens, 2013; 9 (2): e1003134 DOI: 10.1371/journal.ppat.1003134

Cite This Page:

Princeton University. "Drug-resistant MRSA bacteria: Here to stay in both hospital and community." ScienceDaily. ScienceDaily, 15 March 2013. <www.sciencedaily.com/releases/2013/03/130315202724.htm>.
Princeton University. (2013, March 15). Drug-resistant MRSA bacteria: Here to stay in both hospital and community. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2013/03/130315202724.htm
Princeton University. "Drug-resistant MRSA bacteria: Here to stay in both hospital and community." ScienceDaily. www.sciencedaily.com/releases/2013/03/130315202724.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) — Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) — A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) — Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) — California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins