Featured Research

from universities, journals, and other organizations

Oral estrogen hormone therapy linked to increased risk of gallbladder surgery in menopausal women

Date:
March 18, 2013
Source:
Canadian Medical Association Journal
Summary:
Oral estrogen therapy for menopausal women is associated with an increased risk of gallbladder surgery, according to a large-scale study of more than 70 000 women in France).

Oral estrogen therapy for menopausal women is associated with an increased risk of gallbladder surgery, according to a large-scale study of more than 70 000 women in France published in CMAJ (Canadian Medical Association Journal)

Women who took estrogen therapy through skin patches or gels did not appear to be at increased risk.

Gallstone disease is common in developed countries, and women over age 50 are most at risk. Other risk factors include obesity, diabetes, high cholesterol, poor diet and having given birth to two or more children.

A large study of 70 928 menopausal women in France between 1992 and 2008 looked at whether hormone therapy increased the risk of gallbladder surgery (cholecystectomy) for complications of gallstones. In France, hormonal therapy is usually administered topically rather than orally. North America and the United Kingdom prefer oral hormone therapies.

"In this large French prospective cohort study, we found that the risk of cholecystectomy was increased among women exposed to oral estrogen regiments for menopausal hormone therapy, especially oral regimens without progestagen," writes Dr. Antoine Racine, Institut national de la santé et de la recherche médicale (INSERM) and Université Paris Sud, with coauthors. "Other types of menopausal hormone therapy were not associated with an increased risk of cholecystectomy."

"Complicated gallstone disease should be added to the list of potential adverse events to be considered when balancing the benefits and risks associated with menopausal hormone therapy," the authors conclude.

In a related commentary, Dr. Bette Liu, Faculty of Medicine, University of New South Wales, Sydney, Australia, writes that the findings of this study support current recommendations for minimizing doses and duration of hormone therapy for menopausal symptoms. However, if hormone therapy is considered necessary, transdermal formulations (such as patches or gels) may have fewer adverse effects than oral formulations.

"Unfortunately there are no large clinical trials comparing transdermal and oral therapies, and such trials will probably never be conducted," she writes. "Evidence to guide recommendations on the best route of hormone administration for individual women and prescribers will thus be limited to the growing volume of observational data. These data suggest that the overall risk-benefit profile of transdermal menopausal hormone therapy makes it a more attractive option than oral therapies."


Story Source:

The above story is based on materials provided by Canadian Medical Association Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Antoine Racine, Anne Bijon, Agnès Fournier, Sylvie Mesrine, Françoise Clavel-Chapelon, Franck Carbonnel, Marie-Christine Boutron-Ruault. Menopausal hormone therapy and risk of cholecystectomy: a prospective study based on the French E3N cohort. CMAJ, March 18, 2013 DOI: 10.1503/cmaj.121490

Cite This Page:

Canadian Medical Association Journal. "Oral estrogen hormone therapy linked to increased risk of gallbladder surgery in menopausal women." ScienceDaily. ScienceDaily, 18 March 2013. <www.sciencedaily.com/releases/2013/03/130318132631.htm>.
Canadian Medical Association Journal. (2013, March 18). Oral estrogen hormone therapy linked to increased risk of gallbladder surgery in menopausal women. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2013/03/130318132631.htm
Canadian Medical Association Journal. "Oral estrogen hormone therapy linked to increased risk of gallbladder surgery in menopausal women." ScienceDaily. www.sciencedaily.com/releases/2013/03/130318132631.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) — The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) — Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) — A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) — The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins