Featured Research

from universities, journals, and other organizations

Hormone combination shows promise in the treatment of obesity and diabetes

Date:
March 19, 2013
Source:
Society for Endocrinology
Summary:
A new treatment combining two hormones can reduce appetite, according to new research. This early study provides 'first in human' evidence that a combined therapy using the hormones glucagon and glucagon-like peptide 1 (GLP-1) may form the basis for a new treatment for obesity and diabetes in the future.

A new treatment combining two hormones can reduce appetite, according to new research presented today at the Society for Endocrinology annual conference in Harrogate, UK. This early study from an internationally-renowned team at Imperial College London provides 'first in human' evidence that a combined therapy using the hormones glucagon and glucagon-like peptide 1 (GLP-1) may form the basis for a new treatment for obesity and diabetes in the future.

Previous results from in animal studies showed that glucagon/GLP-1 combination might be an effective lead to combat obesity and diabetes. The hormones play key roles in regulating blood sugar. Glucagon works in opposition to insulin, preventing the storage of glucose in fat deposits and the liver, and raising blood sugar levels. GLP-1 stimulates the release of insulin to lower blood sugar and also acts at the brain to reduce appetite.

The research team, led by Professor Stephen Bloom, set out to identify whether glucagon and GLP-1 given in combination might work together to reduce appetite. In this small study, 16 human volunteers were randomly allocated to a sequence of four treatment infusions for 120 minutes, separated by at least three days, each: 1) glucagon, 2) GLP-1, 3) glucagon and GLP-1 in combination and 4) a saline infusion as a control. Double-blind crossover experiments such as these are used across clinical research to reliably identify cause and effect in a series of interventions.

The team provided the subjects with a meal at 90 minutes into each infusion, measured the amount of oxygen consumed, took blood samples to measure blood sugar and metabolic hormone levels, and took readings for pulse, blood pressure and nausea, all both at baseline and during the infusions. This provided data on energy intake (amount of food consumed), energy expenditure (oxygen used), blood sugar control, and the safety of and tolerance to the treatment.

The energy intake during the meal was 1086+/-110.1kcal for the control group vs. 879+/-94.2kcal for the hormone combination group: a significant reduction of 13% (p<0.05) which was also not seen when either hormone was given alone (glucagon: 1086+/-96.9kcal, GLP-1: 1052+/-81.3kcal; p>0.05). A non-significant trend toward increased energy expenditure was also observed in the combination and glucagon-alone groups. The infusions were tolerated safely.

The data show that the promising findings using a glucagon/GLP-1 combination in mice can be replicated in man. Appetite was significantly reduced during the combination treatment compared to the glucagon, GLP-1 alone or saline infusions. The group must now test this glucagon/GLP-1 combination treatment in more people and for longer periods of time to see if the effects can be sustained in the long term.

Professor Stephen Bloom, Head of Division of Diabetes, Endocrinology and Metabolism at Imperial College London said: "The hormones glucagon and GLP-1 are both used by the body to control blood sugar and metabolism, so there is great interest in utilising them to find new treatments for obesity and type 2 diabetes.

"We found that volunteers treated with a glucagon/GLP-1 combination consumed significantly less food. These data replicate our findings in animals, suggesting that a glucagon/GLP-1 combination may be a promising lead from which to develop a new treatment for obesity and diabetes.

"13% is a big reduction in food intake by anyone's standards, but our experiment is only an appetiser. An effective future treatment will need to suppress appetite in the long term, so we next aim to establish whether the effects can be sustained to lead to real weight loss."


Story Source:

The above story is based on materials provided by Society for Endocrinology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jaimini Cegla, Rachel Troke, Ben Jones, George Tharakan, Katherine McCullough, Julia Wilde, Chung Thong Lim, Naseem Parvizi, Mohamed Hussein, James Minnion, Joyceline Cuenco, Edward Chambers, Mohammad Ghatei, Tricia Tan, Stephen Bloom. Energy intake following infusion of glucagon and GLP-1: a double-blind crossover study. Endocrine Abstracts, 2013; 1 DOI: 10.1530/endoabs.31.OC4.5

Cite This Page:

Society for Endocrinology. "Hormone combination shows promise in the treatment of obesity and diabetes." ScienceDaily. ScienceDaily, 19 March 2013. <www.sciencedaily.com/releases/2013/03/130318203332.htm>.
Society for Endocrinology. (2013, March 19). Hormone combination shows promise in the treatment of obesity and diabetes. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2013/03/130318203332.htm
Society for Endocrinology. "Hormone combination shows promise in the treatment of obesity and diabetes." ScienceDaily. www.sciencedaily.com/releases/2013/03/130318203332.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins