Featured Research

from universities, journals, and other organizations

What you eat before surgery may affect your recovery

Date:
March 21, 2013
Source:
Brigham and Women's Hospital
Summary:
According to a new study, the last few meals before surgery might make a difference in recovery after surgery.

A new study suggests that altering food intake before surgery may affect the body's response post-surgery.
Credit: Ozaki Lab, Brigham and Women's Hospital

According to a new study, the last few meals before surgery might make a difference in recovery after surgery. Fat tissue is one of the most dominant components that make up the body, and fat tissue is always traumatized during major surgery.

Related Articles


Researchers at Brigham and Women's Hospital (BWH) found that this direct trauma greatly impacts the chemical balance of fat tissue -- chemicals that are known to communicate with nearby and distant organs. In the study, mice that consumed a typical Western, high-fat diet showed an exaggerated imbalanced response. Importantly, restricting food intake to a lower-fat diet just a few weeks before surgery reduced the imbalance back toward a more normal response.

The study is published in the April 2013 issue of Surgery.

Senior study author C. Keith Ozaki, MD, Director of BWH Vascular Surgery Research, and colleagues measured how fat responds to surgery and whether restricting calorie intake before surgery changed how the fat tissue responded to typical trauma that usually occurs during an operation.

"Surgeons have learned that generally minimizing trauma accelerates patient recovery from surgery," noted Ozaki. "While we do this well for specific organs such as the heart, blood vessels, liver, and so forth, we historically have paid little attention to the fat that we cut through to expose these organs. Our findings challenge us all to learn more about how fat responds to trauma, what factors impact this response, and how fat's response is linked to the outcome of individual patients."

Researchers fed one group of mice a high-fat diet (containing 60 percent calories from fat), while a control group was given a more normal diet (containing 10 percent calories from fat).

Three weeks before surgery, researchers switched some of the high-fat diet mice to the normal diet. During surgery, the researchers performed procedures that would occur during a typical operation and observed that such surgical trauma rapidly affected the fat tissues located both near and away from the trauma site. This resulted in increased inflammation and decreased specialized fat hormone synthesis, especially in the young adult mice and those that had a simulated wound infection.

However, reducing food intake before surgery tended to reverse these activities for all mice age groups, even in the setting of the simulated infection. The results suggest that while fat is a very dominant tissue in the human body, its ability to rapidly change might be leveraged to lessen complications in humans during stressful situations such as surgery.

In an accompanying review article composed with key collaborator James Mitchell, PhD, assistant professor of Genetics and Complex Diseases, Harvard School of Public Health, the researchers suggest that restricting diet in humans before surgery provides a unique opportunity to test whether this method will decrease the incidence and severity of surgical complications brought on by over-exuberant inflammation and other stressors.

Simply cutting out certain dietary elements (without malnutrition) may be a feasible, inexpensive and effective way of protecting the body against stress from an operation. In the review article, the researchers specifically point to further studying this method in patients undergoing vascular surgery, a population that faces increased risks of surgical complications such as wound-healing problems, heart attack and stroke.

"The relationship between surgical outcomes and obesity has always been complex," said Ozaki. "Our results and those of others highlight that the quality of your fat tissues appears to be important, along with the total amount of body fat when it comes to the body's response to an operation."


Story Source:

The above story is based on materials provided by Brigham and Women's Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. Binh Nguyen, Ming Tao, Peng Yu, Christine Mauro, Michael A. Seidman, Yaoyu E. Wang, James Mitchell, C. Keith Ozaki. Preoperative diet impacts the adipose tissue response to surgical trauma. Surgery, 2013; 153 (4): 584 DOI: 10.1016/j.surg.2012.11.001

Cite This Page:

Brigham and Women's Hospital. "What you eat before surgery may affect your recovery." ScienceDaily. ScienceDaily, 21 March 2013. <www.sciencedaily.com/releases/2013/03/130321111015.htm>.
Brigham and Women's Hospital. (2013, March 21). What you eat before surgery may affect your recovery. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2013/03/130321111015.htm
Brigham and Women's Hospital. "What you eat before surgery may affect your recovery." ScienceDaily. www.sciencedaily.com/releases/2013/03/130321111015.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins