Featured Research

from universities, journals, and other organizations

Novel serum biomarker bilirubin predicted lung cancer risk in smokers

Date:
April 7, 2013
Source:
American Association for Cancer Research (AACR)
Summary:
Smokers with low bilirubin levels were at increased risk for lung cancer incidence and mortality compared with those who had the highest bilirubin levels, making serum bilirubin a potential biomarker for lung cancer risk prediction.

Smokers with low bilirubin levels were at increased risk for lung cancer incidence and mortality compared with those who had the highest bilirubin levels, making serum bilirubin a potential biomarker for lung cancer risk prediction, according to data presented at the AACR Annual Meeting 2013, held in Washington, D.C., April 6-10.

Related Articles


"Although it was expected that bilirubin may be protective against lung cancer incidence and mortality, we were somewhat surprised that the effect of bilirubin was only evident in smokers, which will have profound public health implications, given that 90 percent of lung cancers occur in smokers," said Xifeng Wu, M.D., Ph.D., professor and chair of the Department of Epidemiology at The University of Texas MD Anderson Cancer Center in Houston.

Most patients with lung cancer are diagnosed at inoperable advanced stages and the prognosis is particularly dismal, with the five-year survival rate for stage 3b and stage 4 diseases being 5 percent and 1 percent, respectively, according to Wu. Biomarkers are urgently needed for improving risk prediction for lung cancer beyond smoking variables, and serum metabolites are emerging as promising markers.

Wu and colleagues used a unique multiphase study design for the metabolomics profiling of serum samples. In the initial discovery phase, the researchers recruited 20 healthy individuals, 20 patients with early-stage non-small cell lung cancer and 20 patients with late-stage non-small cell lung cancer, matched for age and gender. They performed global, unbiased metabolite profiling using the serum from patients' blood samples. They then validated the top three differentially expressed metabolites in the next phase involving two additional populations with a total of 519 healthy individuals and patients with non-small cell lung cancer.

The metabolite bilirubin emerged as the most promising marker, and the researchers further validated this finding in the third phase, which included a large Taiwanese prospective cohort of 435,985 individuals.

Among the Taiwanese cohort, the researchers found a 7.02 incidence rate of lung cancer per 10,000 person-years for men with bilirubin levels of 0.68 mg/dL or less, compared with an incidence rate of 3.73 among men whose bilirubin levels were 1.12 mg/dL or more. This translates into a 51 percent increase in the risk for developing lung cancer for patients with low bilirubin. Researchers also found a lung cancer-specific mortality rate of 4.84 for men with the lowest levels of bilirubin compared with a mortality rate of 2.46 for men with the highest bilirubin levels -- a 59 percent increase in lung cancer-specific mortality among those with the lowest bilirubin levels.

Looking only at smokers, Wu and her colleagues found that those with the lowest levels of bilirubin had a 69 percent increase in the risk for lung cancer development and a 76 percent increase in mortality compared with smokers with the highest levels of bilirubin. In contrast, there was no significant effect of bilirubin in "never-smokers."

The association between bilirubin levels and lung cancer was only significant in "ever-smokers" and men, according to Wu.

"The ability to use low bilirubin to identify higher-risk smokers, over and above the number of 'pack years' smokers report having smoked, has significant public health impact in reducing lung cancer burden," said Wu. "Low levels of bilirubin, established as an objective risk index for lung cancer incidence and mortality, may be viewed by smokers as an urgent health warning to drive them to quit."


Story Source:

The above story is based on materials provided by American Association for Cancer Research (AACR). Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research (AACR). "Novel serum biomarker bilirubin predicted lung cancer risk in smokers." ScienceDaily. ScienceDaily, 7 April 2013. <www.sciencedaily.com/releases/2013/04/130407132903.htm>.
American Association for Cancer Research (AACR). (2013, April 7). Novel serum biomarker bilirubin predicted lung cancer risk in smokers. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2013/04/130407132903.htm
American Association for Cancer Research (AACR). "Novel serum biomarker bilirubin predicted lung cancer risk in smokers." ScienceDaily. www.sciencedaily.com/releases/2013/04/130407132903.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins