Featured Research

from universities, journals, and other organizations

Bone-marrow grafts show promise for some sufferers of low-back pain

Date:
April 11, 2013
Source:
American Academy of Pain Medicine (AAPM)
Summary:
Autologous bio-cellular grafts are increasingly encountered in surgical literature as a means to enhance tissue repair. Biologic graft use has expanded beyond simple platelet rich plasma to encompass bone marrow aspirate concentrate (BMAC) and adipose derived autologous stem cell products. The clinical application of such grafts in the treatment of low back pain is intriguing, but remains unproven.

A new study suggests that the type of bio-cellular grafts increasingly used by surgeons to repair damaged tissue may be useful for treating low-back pain (LBP). However, not all sufferers responded equally to the novel therapy. Results reported April 9 at the 29th Annual Meeting of the American Academy of Pain Medicine ranged from complete pain relief to no improvement.

The procedure involved injecting a concentrated form of bone-marrow cellular aspirate into lumbar discs in patients with clinical and objective evidence of disc degeneration. The results were reported in a poster authored by researchers from the Columbia Interventional Pain Center in Columbia, Mo., and the Bluetail Medical Group in Chesterfield, Mo.

"The results of our case review are encouraging," said Donald J. Meyer, MD, PhD, the study's primary author. "Currently, when conservative treatment measures fail, therapeutic options are limited for individuals with back pain due to disc degeneration. Many resort to disc surgery or spinal fusion with mediocre results. Our goal is to help develop a safe, natural method to boost the body's own capacity to heal discogenic pain."

The practice of using autologous grafts, in which material is transferred from within the same individual's body, has evolved beyond the simple use of platelet-rich plasma to encompass cellular bone-marrow concentrate and cells drawn from body fat, the study authors explained. Intrigued by the technique's possibilities in treating LBP, the team retrospectively examined data for 22 consecutive patients treated at Columbia Interventional Pain Center in Columbia, Mo., over 18 months. Patients had LBP lasting an average of 4 years along with evidence confirming degenerative disc changes via CT scan or MRI. Some patients also complained of leg pain.

Patients were informed of the study's experimental nature and gave informed consent. During the procedure, investigators harvested 60 cc iliac bone-marrow aspirate and concentrated it in a centrifuge to obtain bone-marrow aspirate cellular concentrate (BMAC). They then injected BMAC into each affected lumbar disc annulus using a 22-gauge Chiba needle under fluoroscopy. This was followed by the injection of an additional small amount of BMAC immediately external to the annulus. A maximum of 2 discs were treated.

At 5-24 months following treatment, patients reported changes in back pain ranging from complete pain relief to no improvement. No patient reported a worsening of pain, and no complications occurred. All subjects who experienced pain relief also reported significant improvement in activity tolerance or a reduction in pain medication use, or both.

A future prospective study is warranted, the authors concluded, to examine whether biologic autograft treatment may provide a safe and effective therapy for lumbar discogenic pain.


Story Source:

The above story is based on materials provided by American Academy of Pain Medicine (AAPM). Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Pain Medicine (AAPM). "Bone-marrow grafts show promise for some sufferers of low-back pain." ScienceDaily. ScienceDaily, 11 April 2013. <www.sciencedaily.com/releases/2013/04/130411194020.htm>.
American Academy of Pain Medicine (AAPM). (2013, April 11). Bone-marrow grafts show promise for some sufferers of low-back pain. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2013/04/130411194020.htm
American Academy of Pain Medicine (AAPM). "Bone-marrow grafts show promise for some sufferers of low-back pain." ScienceDaily. www.sciencedaily.com/releases/2013/04/130411194020.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins