Featured Research

from universities, journals, and other organizations

Bone-marrow grafts show promise for some sufferers of low-back pain

Date:
April 11, 2013
Source:
American Academy of Pain Medicine (AAPM)
Summary:
Autologous bio-cellular grafts are increasingly encountered in surgical literature as a means to enhance tissue repair. Biologic graft use has expanded beyond simple platelet rich plasma to encompass bone marrow aspirate concentrate (BMAC) and adipose derived autologous stem cell products. The clinical application of such grafts in the treatment of low back pain is intriguing, but remains unproven.

A new study suggests that the type of bio-cellular grafts increasingly used by surgeons to repair damaged tissue may be useful for treating low-back pain (LBP). However, not all sufferers responded equally to the novel therapy. Results reported April 9 at the 29th Annual Meeting of the American Academy of Pain Medicine ranged from complete pain relief to no improvement.

The procedure involved injecting a concentrated form of bone-marrow cellular aspirate into lumbar discs in patients with clinical and objective evidence of disc degeneration. The results were reported in a poster authored by researchers from the Columbia Interventional Pain Center in Columbia, Mo., and the Bluetail Medical Group in Chesterfield, Mo.

"The results of our case review are encouraging," said Donald J. Meyer, MD, PhD, the study's primary author. "Currently, when conservative treatment measures fail, therapeutic options are limited for individuals with back pain due to disc degeneration. Many resort to disc surgery or spinal fusion with mediocre results. Our goal is to help develop a safe, natural method to boost the body's own capacity to heal discogenic pain."

The practice of using autologous grafts, in which material is transferred from within the same individual's body, has evolved beyond the simple use of platelet-rich plasma to encompass cellular bone-marrow concentrate and cells drawn from body fat, the study authors explained. Intrigued by the technique's possibilities in treating LBP, the team retrospectively examined data for 22 consecutive patients treated at Columbia Interventional Pain Center in Columbia, Mo., over 18 months. Patients had LBP lasting an average of 4 years along with evidence confirming degenerative disc changes via CT scan or MRI. Some patients also complained of leg pain.

Patients were informed of the study's experimental nature and gave informed consent. During the procedure, investigators harvested 60 cc iliac bone-marrow aspirate and concentrated it in a centrifuge to obtain bone-marrow aspirate cellular concentrate (BMAC). They then injected BMAC into each affected lumbar disc annulus using a 22-gauge Chiba needle under fluoroscopy. This was followed by the injection of an additional small amount of BMAC immediately external to the annulus. A maximum of 2 discs were treated.

At 5-24 months following treatment, patients reported changes in back pain ranging from complete pain relief to no improvement. No patient reported a worsening of pain, and no complications occurred. All subjects who experienced pain relief also reported significant improvement in activity tolerance or a reduction in pain medication use, or both.

A future prospective study is warranted, the authors concluded, to examine whether biologic autograft treatment may provide a safe and effective therapy for lumbar discogenic pain.


Story Source:

The above story is based on materials provided by American Academy of Pain Medicine (AAPM). Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Pain Medicine (AAPM). "Bone-marrow grafts show promise for some sufferers of low-back pain." ScienceDaily. ScienceDaily, 11 April 2013. <www.sciencedaily.com/releases/2013/04/130411194020.htm>.
American Academy of Pain Medicine (AAPM). (2013, April 11). Bone-marrow grafts show promise for some sufferers of low-back pain. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2013/04/130411194020.htm
American Academy of Pain Medicine (AAPM). "Bone-marrow grafts show promise for some sufferers of low-back pain." ScienceDaily. www.sciencedaily.com/releases/2013/04/130411194020.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) — Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Reasons Why Teen Birth Rates Are At An All-Time Low

Reasons Why Teen Birth Rates Are At An All-Time Low

Newsy (Aug. 20, 2014) — A CDC report says birth rates among teenagers have been declining for decades, reaching a new low in 2013. We look at several popular explanations. Video provided by Newsy
Powered by NewsLook.com
Common Antibiotic Could Lead To Heart-Related Death

Common Antibiotic Could Lead To Heart-Related Death

Newsy (Aug. 20, 2014) — Danish researchers discovered patients taking clarithromycin have an increased risk of dying from a heart-related issue. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins