Featured Research

from universities, journals, and other organizations

Study on patients with disc prolapse: Same gene variant promotes pain in women, suppresses pain in men

Date:
April 12, 2013
Source:
The Research Council of Norway
Summary:
More women than men develop chronic low back pain and sciatica. The explanation may lie with a gene variant that plays into the body’s pain regulation.

More women than men develop chronic low back pain and sciatica. The explanation may lie with a gene variant that plays into the body's pain regulation.

"In our study we were surprised to discover that the same gene variant may actually promote chronic pain in women and suppress pain in men," says Professor Johannes Gjerstad, Senior Researcher at the Norwegian National Institute of Occupational Health (STAMI).

Professor Gjerstad headed a research project encompassing nearly 300 patients suffering from disc prolapse at Oslo University Hospital and at Haukeland University Hospital in Bergen. Patients were followed up for one year after admission. The project received funding from the Research Council of Norway's Programme on Clinical Research (KLINISKFORSKNING).

Men recover more quickly from back pain compared to women, a Norwegian study shows. (Illustrative photo: Shutterstock) Twice as much pain

Although everyone basically has the same genes, there are many genes that come in multiple versions -- an ordinary one and a variant. Generally, the effects of this genetic variation are gender-independent, but there are exceptions.

"As expected, somewhat more men than women were referred to hospital with disc prolapse," continues Professor Gjerstad. "In the course of the study we observed that the men recovered faster than the women." Previous research findings on animals provided the researchers with a clue that the gene coding for the OPRM1 receptor -- involved in the body's pain regulation -- may be responsible for this.

It turns out that the women with the less ordinary variant of this gene often experienced twice as much pain as the men who had the same gene variant. One year after their prolapse, on a pain scale from 0 to 10, these women reported an average intensity of around four, while the men averaged around two.

Roughly one in four persons, independent of gender, carries this unfortunate gene variant.

At least six in ten people suffer back pain

An estimated 60 to 80 per cent of Norway's population experience low back pain at some point in life. No single condition costs society more in social insurance benefits. Why some people develop chronic back pain after a prolapse and others do not has long been a mystery.

Previous research data shows that a gene coding for the COMT receptor plays a role in the experience of pain half a year after a disc prolapse. The gene coding for the OPRM1 receptor, however, appears to become significant only after a full year.

The patients in the study reported their pain by questionnaire. One year post-prolapse, two out of three back patients had healed completely. But the remaining third, most of them women, continued to experience discomfort.

The insights gained from the Norwegian study may ultimately help researchers to customise prevention and treatment better.

A factor in other types of pain?

The OPRM1 receptor has no direct significance for the back's physical condition, but rather is known to play a key role in the brain's regulation of pain. For this reason the researchers believe their findings may be relevant to other experiences of pain.

"We think that this OPRM1 gene variant is significant for long-term pain more generally, and we would like to investigate this further," says Professor Gjerstad.

In addition they hope to study the relationship between genetic factors and, for instance, sick leave and disability.

Combination of genes and environment

How is it possible that the same gene variant has different effects on men and women? The answer is complex, but in short it has to do with the inherent differences between men's and women's brains.

Professor Gjerstad stresses that although the OPRM1 gene is an important contributing factor, it does not fully account for why some people develop chronic back pain and others do not.

"The gene variant we have studied does not in itself cause chronic pain -- nor is a man or woman who has this 'unlucky' gene variant doomed to suffer back pain," he clarifies. "Environmental factors such as psychosocial workload definitely play a role along with these genes."

The researchers will now collaborate with a research group in Finland to attempt to replicate these findings with a larger sample of employees.


Story Source:

The above story is based on materials provided by The Research Council of Norway. The original article was written by Elin Fugelsnes/Else Lie. Translation: Darren McKellep/Carol B. Eckmann. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. B. Olsen, L. M. Jacobsen, E. I. Schistad, L. M. Pedersen, L. J. Rygh, C. Roe, J. Gjerstad. Pain Intensity the First Year after Lumbar Disc Herniation Is Associated with the A118G Polymorphism in the Opioid Receptor Mu 1 Gene: Evidence of a Sex and Genotype Interaction. Journal of Neuroscience, 2012; 32 (29): 9831 DOI: 10.1523/JNEUROSCI.1742-12.2012

Cite This Page:

The Research Council of Norway. "Study on patients with disc prolapse: Same gene variant promotes pain in women, suppresses pain in men." ScienceDaily. ScienceDaily, 12 April 2013. <www.sciencedaily.com/releases/2013/04/130412084535.htm>.
The Research Council of Norway. (2013, April 12). Study on patients with disc prolapse: Same gene variant promotes pain in women, suppresses pain in men. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2013/04/130412084535.htm
The Research Council of Norway. "Study on patients with disc prolapse: Same gene variant promotes pain in women, suppresses pain in men." ScienceDaily. www.sciencedaily.com/releases/2013/04/130412084535.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) — Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) — A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) — Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) — President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins