Featured Research

from universities, journals, and other organizations

Can new plasma-based biomaterials speed healing of injured tissues?

Date:
April 15, 2013
Source:
Mary Ann Liebert, Inc., Publishers
Summary:
Platelet-rich plasma (PRP) derived from blood contains growth factors and other bioactive molecules that promote healing at sites of tissue injury. However, it is difficult to deliver and retain these molecules at a target site, and clinical results have proven to be mixed – until now. A new solid form of bioactive plasma-based biomaterials, known as PBMs, can accelerate tissue healing. Not only are PBMs easier to work with, inexpensive to produce, and safe to use, they are available as off-the-shelf products.

Platelet-rich plasma (PRP) derived from blood contains growth factors and other bioactive molecules that promote healing at sites of tissue injury. However, it is difficult to deliver and retain these molecules at a target site, and clinical results have proven to be mixed -- until now. A new solid form of bioactive plasma-based biomaterials, known as PBMs, can accelerate tissue healing. Not only are PBMs easier to work with, inexpensive to produce, and safe to use, they are available as off-the-shelf products. All of these promising advantages, and the potential to use PBMs to enhance healing of difficult-to-treat connective tissue injuries affecting cartilage, tendons, and ligaments, contribute to their unique possibilities.

Related Articles


Authors Jason Smith and Alan West, Carmell Therapeutics Corp.; Lee Weiss, Robotics Institute, and Phil Campbell, Institute for Complex Engineered Systems, Carnegie Mellon University; and James Burgess, Department of Neurosurgery, Allegheny General Hospital, Pittsburgh, PA, describe initial studies with PBMs in which they were successfully used to stimulate the repair of a bone defect in a mouse. They conclude that "PBM products have the potential to accelerate healing and reduce pain and complications, enabling patients to return to work and their daily lives more quickly." The authors further discuss the development of the PBM technology, its potential applications, advantages over existing treatment options, and the barriers still to be overcome for clinical implementation.

According to study author Alan West, "There has been much recent interest in the concept of using natural regenerative factors to heal wounds -- the use of autologous platelet-rich plasma is seeing wide-scale clinical use for treating musculoskeletal and other injuries. Our plasma-based biomaterials move this concept a quantum leap forward, with materials that have the potential to disrupt the industry with a new category of biologics that are inexpensive to produce, safe, and robust in healing both bone and soft tissue injuries."

"There is a significant need for effective, consistent, and cost effective products that can biologically enhance tissue healing," says Editor-in-Chief Alan J. Russell, PhD, Highmark Distinguished Professor, Carnegie Mellon University. "By being cost effective and readily available, PBMs can benefit a wide population of patients in healthcare systems. The research Smith and his colleagues have published has the potential to benefit not only the First World Countries, but also could be practical options for developing nations."


Story Source:

The above story is based on materials provided by Mary Ann Liebert, Inc., Publishers. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jason D. Smith, Lee E. Weiss, James E. Burgess, Alan I. West, Phil G. Campbell. Biologically Active Blood Plasma-Based Biomaterials as a New Paradigm for Tissue Repair Therapies. Disruptive Science and Technology, 2012; 121219064042006 DOI: 10.1089/dst.2012.0024

Cite This Page:

Mary Ann Liebert, Inc., Publishers. "Can new plasma-based biomaterials speed healing of injured tissues?." ScienceDaily. ScienceDaily, 15 April 2013. <www.sciencedaily.com/releases/2013/04/130415124547.htm>.
Mary Ann Liebert, Inc., Publishers. (2013, April 15). Can new plasma-based biomaterials speed healing of injured tissues?. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2013/04/130415124547.htm
Mary Ann Liebert, Inc., Publishers. "Can new plasma-based biomaterials speed healing of injured tissues?." ScienceDaily. www.sciencedaily.com/releases/2013/04/130415124547.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins