Featured Research

from universities, journals, and other organizations

Cancer metastasis: When a KISS (1) goes bad

Date:
April 16, 2013
Source:
University of Western Ontario
Summary:
KISS 1 is a metastasis-suppressor gene which helps to prevent the spread of cancers, including melanoma, pancreatic and ovarian cancers to name a few. But new research shows that kisspeptins -- peptide products of KISS1, actually make some breast cancers worse, with a higher tumor grade and metastatic potential.

KISS 1 is a metastasis-suppressor gene which helps to prevent the spread of cancers, including melanoma, pancreatic and ovarian cancers to name a few. But new research from Western University's Schulich School of Medicine & Dentistry shows that kisspeptins -peptide products of KISS1, actually make some breast cancers worse, with a higher tumor grade and metastatic potential. The research is published online in the journal Endocrinology.

Related Articles


Moshmi Bhattacharya, an associate professor in the Departments of Physiology and Pharmacology, and Oncology, was surprised to find high levels of kisspeptins in aggressive breast cancers. "We found kisspeptins could turn non-invasive cancer cells into invasive cells, and therefore could be playing a role in the metastasis of breast cancer."

The paper's first author Donna Cvetkovic, a graduate student working with Bhattacharya, says they were also able to pinpoint what triggered kisspeptin to act in this unusual fashion. "Typically breast cancers are classified as being estrogen receptor-positive or estrogen receptor-negative. In estrogen receptor-negative cells we found that kisspeptin significantly increased invasiveness. However in cells that still expressed estrogen, kisspeptin does not lead to invasion," says Cvetkovic. "We believe that estrogen is acting as a brake, and when patients lose their estrogen receptor, it allows kisspeptin to behave in a non-typical fashion."

"As for clinical applications, testing to see whether the kisspeptin receptor is present or not, could provide us with an idea of whether the breast cancer will become more aggressive and thereby more metastatic," says Bhattacharya, a New Investigator with the Canadian Institutes of Health Research (CIHR) which funded this study. She also believes kisspeptins could be a good therapeutic target.


Story Source:

The above story is based on materials provided by University of Western Ontario. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Cvetkovic, M. Dragan, S. J. Leith, Z. M. Mir, H. S. Leong, M. Pampillo, A. V. Babwah, M. Bhattacharya. KISS1R Induces Invasiveness of Estrogen Receptor-Negative Human Mammary Epithelial and Breast Cancer Cells. Endocrinology, 2013; DOI: 10.1210/en.2012-2164

Cite This Page:

University of Western Ontario. "Cancer metastasis: When a KISS (1) goes bad." ScienceDaily. ScienceDaily, 16 April 2013. <www.sciencedaily.com/releases/2013/04/130416132811.htm>.
University of Western Ontario. (2013, April 16). Cancer metastasis: When a KISS (1) goes bad. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/2013/04/130416132811.htm
University of Western Ontario. "Cancer metastasis: When a KISS (1) goes bad." ScienceDaily. www.sciencedaily.com/releases/2013/04/130416132811.htm (accessed February 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, February 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins