Featured Research

from universities, journals, and other organizations

Cancer metastasis: When a KISS (1) goes bad

Date:
April 16, 2013
Source:
University of Western Ontario
Summary:
KISS 1 is a metastasis-suppressor gene which helps to prevent the spread of cancers, including melanoma, pancreatic and ovarian cancers to name a few. But new research shows that kisspeptins -- peptide products of KISS1, actually make some breast cancers worse, with a higher tumor grade and metastatic potential.

KISS 1 is a metastasis-suppressor gene which helps to prevent the spread of cancers, including melanoma, pancreatic and ovarian cancers to name a few. But new research from Western University's Schulich School of Medicine & Dentistry shows that kisspeptins -peptide products of KISS1, actually make some breast cancers worse, with a higher tumor grade and metastatic potential. The research is published online in the journal Endocrinology.

Related Articles


Moshmi Bhattacharya, an associate professor in the Departments of Physiology and Pharmacology, and Oncology, was surprised to find high levels of kisspeptins in aggressive breast cancers. "We found kisspeptins could turn non-invasive cancer cells into invasive cells, and therefore could be playing a role in the metastasis of breast cancer."

The paper's first author Donna Cvetkovic, a graduate student working with Bhattacharya, says they were also able to pinpoint what triggered kisspeptin to act in this unusual fashion. "Typically breast cancers are classified as being estrogen receptor-positive or estrogen receptor-negative. In estrogen receptor-negative cells we found that kisspeptin significantly increased invasiveness. However in cells that still expressed estrogen, kisspeptin does not lead to invasion," says Cvetkovic. "We believe that estrogen is acting as a brake, and when patients lose their estrogen receptor, it allows kisspeptin to behave in a non-typical fashion."

"As for clinical applications, testing to see whether the kisspeptin receptor is present or not, could provide us with an idea of whether the breast cancer will become more aggressive and thereby more metastatic," says Bhattacharya, a New Investigator with the Canadian Institutes of Health Research (CIHR) which funded this study. She also believes kisspeptins could be a good therapeutic target.


Story Source:

The above story is based on materials provided by University of Western Ontario. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Cvetkovic, M. Dragan, S. J. Leith, Z. M. Mir, H. S. Leong, M. Pampillo, A. V. Babwah, M. Bhattacharya. KISS1R Induces Invasiveness of Estrogen Receptor-Negative Human Mammary Epithelial and Breast Cancer Cells. Endocrinology, 2013; DOI: 10.1210/en.2012-2164

Cite This Page:

University of Western Ontario. "Cancer metastasis: When a KISS (1) goes bad." ScienceDaily. ScienceDaily, 16 April 2013. <www.sciencedaily.com/releases/2013/04/130416132811.htm>.
University of Western Ontario. (2013, April 16). Cancer metastasis: When a KISS (1) goes bad. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2013/04/130416132811.htm
University of Western Ontario. "Cancer metastasis: When a KISS (1) goes bad." ScienceDaily. www.sciencedaily.com/releases/2013/04/130416132811.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins