Featured Research

from universities, journals, and other organizations

Fighting bacteria with new genre of antibodies

Date:
April 24, 2013
Source:
American Chemical Society
Summary:
In an advance toward coping with bacteria that shrug off existing antibiotics and sterilization methods, scientists are reporting development of a new family of selective antimicrobial agents that do not rely on traditional antibiotics. They report on these synthetic colloid particles, which can be custom-designed to recognize the shape of specific kinds of bacteria and inactivate them.

E. coli bacteria illustration. To cope with bacteria that shrug off existing antibiotics and sterilization methods, scientists have developed a new family of selective anti- microbial agents that do not rely on traditional antibiotics.
Credit: iStockphoto/Sebastian Kaulitzki

In an advance toward coping with bacteria that shrug off existing antibiotics and sterilization methods, scientists are reporting development of a new family of selective antimicrobial agents that do not rely on traditional antibiotics.

Their report on these synthetic colloid particles, which can be custom-designed to recognize the shape of specific kinds of bacteria and inactivate them, appears in the Journal of the American Chemical Society.

Vesselin Paunov and colleagues point out that many bacteria have developed resistance to existing antibiotics. They sought a new approach -- one that bacteria would be unable to elude by mutating into drug-resistant forms. Their inspiration was the antibodies that the immune system produces when microbes invade the body. Those antibodies patrol the body for microbes and bind to their surfaces, triggering a chain of events in which the body's immune system attacks and destroys the microbes.

Paunov's team describes development and successful tests of synthetic colloid particles, called "colloid antibodies." Colloids are materials in which tiny particles of one material are dispersed in another material. Milk is a colloid in which globules of fat are spread throughout water and other materials. The colloid antibody particles are shells packed with a killing agent. They are designed to recognize and bind to specific bacteria.

Laboratory experiments showed that the colloid antibodies attached to and inactivated only their intended targets without harming other cells. "We anticipate that similar shape selective colloid antibodies can potentially become a powerful weapon in the fight against antibiotic-resistant bacteria," say the researchers. "They can also find applications as non-toxic antibacterial agents, preventing growth of harmful bacteria in various formulations."


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Josef Borovička, William J. Metheringham, Leigh A. Madden, Christopher D. Walton, Simeon D. Stoyanov, Vesselin N. Paunov. Photothermal Colloid Antibodies for Shape-Selective Recognition and Killing of Microorganisms. Journal of the American Chemical Society, 2013; 135 (14): 5282 DOI: 10.1021/ja400781f

Cite This Page:

American Chemical Society. "Fighting bacteria with new genre of antibodies." ScienceDaily. ScienceDaily, 24 April 2013. <www.sciencedaily.com/releases/2013/04/130424112314.htm>.
American Chemical Society. (2013, April 24). Fighting bacteria with new genre of antibodies. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2013/04/130424112314.htm
American Chemical Society. "Fighting bacteria with new genre of antibodies." ScienceDaily. www.sciencedaily.com/releases/2013/04/130424112314.htm (accessed October 22, 2014).

Share This



More Plants & Animals News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cadaver Dogs Aid Search for More Victims of Suspected Indiana Serial Killer

Cadaver Dogs Aid Search for More Victims of Suspected Indiana Serial Killer

Reuters - US Online Video (Oct. 21, 2014) Police in Gary, Indiana are using cadaver dogs to search for more victims after a suspected serial killer confessed to killing at least seven women. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
White Lion Cubs Unveiled to the Public

White Lion Cubs Unveiled to the Public

Reuters - Light News Video Online (Oct. 21, 2014) Visitors to Belgrade zoo meet a pair of three-week-old lion cubs for the first time. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com
White Lion Cubs Born in Belgrade Zoo

White Lion Cubs Born in Belgrade Zoo

AFP (Oct. 20, 2014) Two white lion cubs, an extremely rare subspecies of the African lion, were recently born at Belgrade Zoo. They are being bottle fed by zoo keepers after they were rejected by their mother after birth. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins