Featured Research

from universities, journals, and other organizations

Antidepressants linked with increased risks after surgery

Date:
April 29, 2013
Source:
University of California, San Francisco (UCSF)
Summary:
Selective serotonin reuptake inhibitors (SSRIs) – among the most widely prescribed antidepressant medications – are associated with increased risk of bleeding, transfusion, hospital readmission and death when taken around the time of surgery, according to a new analysis.

Selective serotonin reuptake inhibitors (SSRIs) -- among the most widely prescribed antidepressant medications -- are associated with increased risk of bleeding, transfusion, hospital readmission and death when taken around the time of surgery, according to an analysis led by researchers at UC San Francisco and Baystate Medical Center in Springfield, Mass.

Related Articles


The scientists looked at the medical records of more than 530,000 patients who underwent surgery at 375 U.S. hospitals between 2006 and 2008. Their results will be published on April 29 in JAMA Internal Medicine.

"There have been small studies that suggested there was a problem, but it has never been well-proven," said lead author Andrew D. Auerbach, MD, MPH, a UCSF professor of medicine. "With this huge data set, we feel confident in saying that SSRIs are associated with about a 10 percent increased risk for these adverse outcomes."

The study authors noted that patients on SSRIs are more likely to have conditions that in themselves increase surgical risk, such as obesity, chronic pulmonary disease and depression.

To address the question of whether these factors might have accounted for the differences in outcomes, they retrospectively matched patients who had taken SSRIs with patients who were not taking the drugs. After matching and controlling for variables such as age, gender, medical condition and depression, they found that patients on SSRIs still were at increased risk.

The scientists also looked at whether the increased risk could be accounted for by patients receiving SSRIs for the first time before surgery. "This was not the case," said Auerbach. "These drugs are almost never used acutely. They are prescribed for chronic conditions such as depression, almost always for long-term use."

The study was not designed to look at possible causes for the increased risk. However, noted Auerbach, SSRIs are known to interfere with the functioning of platelets -- blood cells that play a crucial role in blood clotting. In turn, platelet dysfunction can lead to excess bleeding.

Auerbach cautioned that since the study was retrospective, "a prospective observational study, in which patients are randomly assigned to take SSRIs around the time of surgery, is still needed."

He said that while it would be premature to advise patients not to take SSRIs before surgery, "it's definitely worth discussing with your surgeon or primary care physician."

Co-authors of the paper are Eric Vittinghoff, PhD and Judith Maselli, MSPH, of UCSF; Penelope S. Pekow, PhD, of the University of Massachusetts Amherst and Baystate Medical Center; John Q. Young, MD, of UCSF; and senior author Peter K. Lindenauer, MD, MSc of Baystate Medical Center and Tufts University.

The study was supported by funds from the National Heart, Lung and Blood Institute (K24HL098372).


Story Source:

The above story is based on materials provided by University of California, San Francisco (UCSF). The original article was written by Juliana Bunim. Note: Materials may be edited for content and length.


Journal Reference:

  1. Andrew D. Auerbach et al. Perioperative Use of Selective Serotonin Reuptake Inhibitors and Risks for Adverse Outcomes of Surgery. JAMA Internal Medicine, 2013 DOI: 10.1001/jamainternmed.2013.714

Cite This Page:

University of California, San Francisco (UCSF). "Antidepressants linked with increased risks after surgery." ScienceDaily. ScienceDaily, 29 April 2013. <www.sciencedaily.com/releases/2013/04/130429164638.htm>.
University of California, San Francisco (UCSF). (2013, April 29). Antidepressants linked with increased risks after surgery. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2013/04/130429164638.htm
University of California, San Francisco (UCSF). "Antidepressants linked with increased risks after surgery." ScienceDaily. www.sciencedaily.com/releases/2013/04/130429164638.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins