Featured Research

from universities, journals, and other organizations

Zebrafish study suggests that vitamin B2 (riboflavin) is an antidote to cyanide poisoning

Date:
April 30, 2013
Source:
Federation of American Societies for Experimental Biology
Summary:
With the remains of a recent lottery winner having been exhumed for foul play related to cyanide poisoning, future winners might wonder how they can avoid the same fate. A new report involving zebrafish suggests that riboflavin may mitigate cyanide's toxic effects.

With the remains of a recent lottery winner having been exhumed for foul play related to cyanide poisoning, future winners might wonder what they can do to avoid the same fate. A new report in The FASEB Journal involving zebrafish suggests that riboflavin, also known as vitamin B2, may mitigate the toxic effects of this infamous poison. In addition, the report shows that zebrafish are a viable model for investigating the effects of cyanide on humans. As with any research involving animal models, these findings are preliminary until thoroughly tested in clinical trials. Anyone who suspects cyanide poisoning should not attempt to use riboflavin as an antidote, and instead contact local poison control centers or emergency health services immediately.

"We are encouraged to see that many of the effects of cyanide on zebrafish mirror the effects on humans," said Randall Peterson, Ph.D., a researcher involved in the work from the Harvard Medical School in Boston, Massachusetts. "Hopefully, the cyanide biomarkers and antidotes we discover with the help of zebrafish can one day improve our ability to diagnose and treat humans affected by cyanide poisoning."

To make this discovery, scientists exposed zebrafish to cyanide and measured the effects on their behavior, heart rate and survival. The chemical changes that occurred were measured using a mass spectrometer. The effects in zebrafish were then compared to the effects of cyanide on rabbits and humans. Many of the effects in zebrafish matched those seen in rabbits and humans, confirming that the zebrafish could be used as a model of human cyanide exposure. From there, researchers systematically tested thousands of known drugs to see if any of them could protect the zebrafish from cyanide toxicity and found four drugs, including riboflavin. The study also identified new biomarkers that indicate cyanide exposure and may be clinically useful for the diagnosis of cyanide exposure and the development of antidotes.

"Lottery winners are not the only ones who have to worry about cyanide poisoning," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Cyanide exposure also occurs through smoke inhalation, industrial accidents, acts of war, and even as an unwanted byproduct of useful drugs. Therefore, the development of antidotes is crucial, and it's nice to know that a likely candidate is already on the drugstore shelf."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. K. Nath, L. D. Roberts, Y. Liu, S. B. Mahon, S. Kim, J. H. Ryu, A. Werdich, J. L. Januzzi, G. R. Boss, G. A. Rockwood, C. A. MacRae, M. Brenner, R. E. Gerszten, R. T. Peterson. Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. The FASEB Journal, 2013; 27 (5): 1928 DOI: 10.1096/fj.12-225037

Cite This Page:

Federation of American Societies for Experimental Biology. "Zebrafish study suggests that vitamin B2 (riboflavin) is an antidote to cyanide poisoning." ScienceDaily. ScienceDaily, 30 April 2013. <www.sciencedaily.com/releases/2013/04/130430131527.htm>.
Federation of American Societies for Experimental Biology. (2013, April 30). Zebrafish study suggests that vitamin B2 (riboflavin) is an antidote to cyanide poisoning. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2013/04/130430131527.htm
Federation of American Societies for Experimental Biology. "Zebrafish study suggests that vitamin B2 (riboflavin) is an antidote to cyanide poisoning." ScienceDaily. www.sciencedaily.com/releases/2013/04/130430131527.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Raw: Elephant Undergoes Surgery in Tbilisi Zoo

Raw: Elephant Undergoes Surgery in Tbilisi Zoo

AP (Sep. 18, 2014) Grand the elephant has successfully undergone surgery to remove a portion of infected tusk at Tbilisi Zoo in Georgia. British veterinary surgeons used an electric drill to extract the infected piece. (Sept. 18) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins