Featured Research

from universities, journals, and other organizations

Link between heart, blood, and skeletal muscle

Date:
May 2, 2013
Source:
University of Minnesota Academic Health Center
Summary:
New research has shown that by turning on just a single gene, Mesp1, different cell types including the heart, blood and muscle can be created from stem cells.

Gene thought to make heart tissues turns out to make blood and muscles as well

Related Articles


New research out of the Lillehei Heart Institute at the University of Minnesota shows that by turning on just a single gene, Mesp1, different cell types including the heart, blood and muscle can be created from stem cells. The study was published in the journal Cell Stem Cell.

"Previous research indicated that this gene was the "master regulator" for development of the heart, and that its activity prevented the differentiation of other cell types," said Michael Kyba, Ph.D., associate professor in the University of Minnesota Medical School Department of Pediatrics and a Lillehei endowed scholar. "Our work reveals that this gene acts differently, and that it plays a role in the development of blood and skeletal muscle as well. The outcome depends on the chemical signals that cells expressing this factor sense in their environment."

The research was conducted in the Kyba Lab by lead author Sunny Chan, Ph.D., a postdoctoral associate in the lab.

Stem cell researchers have been trying to generate different cell types for regenerative medicine for years. The gene Mesp1 was particularly interesting to cardiac researchers because it was believed to be a master regulator, sitting at the pinnacle of a gene hierarchy driving cardiac differentiation, blocking the differentiation of other cell types.

However, this research turns that assumption on its head.

A carefully designed study, aimed at understanding precisely what Mesp1 does at different points in time as stem cells develop, revealed that the gene can do so much more than previously thought.

By turning Mesp1 on and off at specific time windows and fine-tuning the culture environment, stem cells can be coached to become not just heart cells, but also blood and muscle cells.

"This is totally out of the blue, but our discovery brings some conflicting findings about Mesp1 together," said Chan. "Some previous studies reported Mesp1 could not make heart cells in certain contexts. We now know why."

The Kyba team further shows Mesp1 is present in the cells that go on to become adult stem cells in the bone marrow which form new blood cells, and stem cells in the skeletal muscles, which form new muscle fibers.

"We are amazed at what a single gene can do," said Chan. "By understanding what Mesp1 does, we are more likely to make different cell types from stem cells more efficiently. We are one step closer to using stem cell technology for regenerative medicine."

Funding for this study was provided by National Institutes for Health (NIH) grants U01 HL100407 and R01 AR055685, along with contributions from the American Heart Association-Jon Holden DeHaan Foundation. Additional grants from the NIH support researchers involved in this project: T32 AR007612 and T32 HL069764.


Story Source:

The above story is based on materials provided by University of Minnesota Academic Health Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sunny Sun-Kin Chan, Xiaozhong Shi, Akira Toyama, Robert W. Arpke, Abhijit Dandapat, Michelina Iacovino, Jinjoo Kang, Gengyun Le, Hannah R. Hagen, Daniel J. Garry, Michael Kyba. Mesp1 Patterns Mesoderm into Cardiac, Hematopoietic, or Skeletal Myogenic Progenitors in a Context-Dependent Manner. Cell Stem Cell, 2013; 12 (5): 587 DOI: 10.1016/j.stem.2013.03.004

Cite This Page:

University of Minnesota Academic Health Center. "Link between heart, blood, and skeletal muscle." ScienceDaily. ScienceDaily, 2 May 2013. <www.sciencedaily.com/releases/2013/05/130502185425.htm>.
University of Minnesota Academic Health Center. (2013, May 2). Link between heart, blood, and skeletal muscle. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2013/05/130502185425.htm
University of Minnesota Academic Health Center. "Link between heart, blood, and skeletal muscle." ScienceDaily. www.sciencedaily.com/releases/2013/05/130502185425.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins