Featured Research

from universities, journals, and other organizations

Level of dengue virus needed for transmission defined

Date:
May 14, 2013
Source:
Wellcome Trust
Summary:
Researchers have identified the dose of dengue virus in human blood that is required to infect mosquitoes when they bite. Mosquitoes are essential for transmitting the virus between people so the findings have important implications for understanding how to slow the spread of the disease.

Researchers have identified the dose of dengue virus in human blood that is required to infect mosquitoes when they bite. Mosquitoes are essential for transmitting the virus between people so the findings have important implications for understanding how to slow the spread of the disease.

Related Articles


By defining the threshold of the amount of virus needed for transmission, the research also provides a target that experimental dengue vaccines and drugs must prevent the virus from reaching in order to be successful at preventing the spread of disease during natural infection.

Dengue, also known as 'breakbone fever', is a viral infection that is transmitted between humans by mosquitoes. In most people it causes flu-like symptoms but in a small proportion of cases the disease can become life-threatening. Recent estimates indicate that there are 390 million infections of dengue across the globe each year and with no vaccine or specific treatment available, current measures to prevent the spread of disease are focused on controlling the mosquito vector.

In research funded by the Wellcome Trust, scientists and doctors at the Oxford University Clinical Research Unit at the Hospital for Tropical Diseases in Vietnam studied the factors that influence the transmission of dengue viruses from dengue patients to the mosquitoes that feed on them. Their findings reveal that mosquitoes that feed on dengue patients with very high levels of virus in their blood are more likely to be infectious to other humans two weeks later.

"Our findings suggest that focused public health intervention strategies to prevent transmission from these 'high risk' spreaders of the virus could have a major impact in slowing the spread of disease," explains Professor Cameron Simmons, a Wellcome Trust Senior Fellow at the Oxford University Clinical Research Unit in Vietnam.

Although the levels of virus in patients who had been hospitalized by the disease were much higher, the majority of patients with mild symptoms who were treated at outpatient centres also had enough virus in their blood to support transmission.

"At the moment, dengue surveillance systems typically only count hospitalized patients but our findings confirm that less serious cases represent an equally important source of virus infection. Since these cases often remain in the community for the duration of their illness, it's important that we explore ways to prevent such patients from providing a source of further virus transmission," added Professor Simmons.

The researchers hope that understanding the level of virus needed for transmission of infection will provide a useful reference point for the development of experimental drugs and vaccines and could be used to inform the endpoints for clinical trials evaluating such interventions.


Story Source:

The above story is based on materials provided by Wellcome Trust. Note: Materials may be edited for content and length.


Cite This Page:

Wellcome Trust. "Level of dengue virus needed for transmission defined." ScienceDaily. ScienceDaily, 14 May 2013. <www.sciencedaily.com/releases/2013/05/130513152832.htm>.
Wellcome Trust. (2013, May 14). Level of dengue virus needed for transmission defined. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2013/05/130513152832.htm
Wellcome Trust. "Level of dengue virus needed for transmission defined." ScienceDaily. www.sciencedaily.com/releases/2013/05/130513152832.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Dinosaur Species Found in Museum Collection

New Dinosaur Species Found in Museum Collection

Reuters - Innovations Video Online (Nov. 27, 2014) A British palaeontologist has discovered a new species of dinosaur while studying fossils in a Canadian museum. Pentaceratops aquilonius was related to Triceratops and lived at the end of the Cretaceous Period, around 75 million years ago. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Classic Hollywood Memorabilia Goes Under the Hammer

Classic Hollywood Memorabilia Goes Under the Hammer

Reuters - Entertainment Video Online (Nov. 26, 2014) The iconic piano from "Casablanca" and the Cowardly Lion suit from "The Wizard of Oz" fetch millions at auction. Sara Hemrajani reports. Video provided by Reuters
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins