Featured Research

from universities, journals, and other organizations

Cutting-edge bacteria research leads to more effective treatment of complex infections

Date:
May 14, 2013
Source:
University of Southern Denmark
Summary:
Bacteria play a huge role when inflammations attack our body. Now researchers have succeeded in revealing one of the devastating effects of bacteria, and thus it will be possible for the pharmaceutical industry to treat even very complicated bacterial infections.

Bacteria are life forms, which, like all other life forms, struggle for the best living conditions for themselves. Therefore they will try to avoid getting attacked by the human immune system, and therefore they have developed various ways to protect themselves from the human immune system. When safe from the immune system, they can focus on breeding and multiplying, and if they become numerous enough, the human body will experience their presence as an infection. Some bacteria are relatively harmless, while others are fatal.

The bacteria avoid being attacked by the human immune system by forming a biofilm -- a surface to protect them against the immune system.

"The biofilm contributes to bacterial resistance, and that can cause severe, persistent infections around heart valve implants and in lungs and the urinary tract," explains postdoc. Mikkel Girke Jψrgensen from the Department of Biochemistry and Molecular Biology at the University of Southern Denmark. Together with professor Poul Valentin-Hansen from the same institution and scientists from American Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, and Georgetown University Medical Center, Washington DC, he stands behind the new discovery.

The researchers now understand the underlying regulatory mechanisms behind the formation of biofilms. The mechanism involves small RNA molecules, which can affect bacterial gene expression and thus the decision of whether to form biofilm or not.

Bacteria can move by using their so-called flagella to swim with. When they need to form biofilms, they "turn off" the flagella, stop moving and start to form a biofilm.

"We have now established what decides whether they swim or not -- and that determines whether they form biofilms or not," explains Mikkel Girke Jψrgensen and continues:

"Prospects for the pharmaceutical industry are huge. This increased understanding of biofilm formation may be the first step in creating new ways to treat complicated infections in the future. "


Story Source:

The above story is based on materials provided by University of Southern Denmark. The original article was written by Birgitte Svennevig. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. G. Jorgensen, M. K. Thomason, J. Havelund, P. Valentin-Hansen, G. Storz. Dual function of the McaS small RNA in controlling biofilm formation. Genes & Development, 2013; DOI: 10.1101/gad.214734.113

Cite This Page:

University of Southern Denmark. "Cutting-edge bacteria research leads to more effective treatment of complex infections." ScienceDaily. ScienceDaily, 14 May 2013. <www.sciencedaily.com/releases/2013/05/130514113249.htm>.
University of Southern Denmark. (2013, May 14). Cutting-edge bacteria research leads to more effective treatment of complex infections. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2013/05/130514113249.htm
University of Southern Denmark. "Cutting-edge bacteria research leads to more effective treatment of complex infections." ScienceDaily. www.sciencedaily.com/releases/2013/05/130514113249.htm (accessed April 24, 2014).

Share This



More Plants & Animals News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Monkeys Are Better At Math Than We Thought, Study Shows

Monkeys Are Better At Math Than We Thought, Study Shows

Newsy (Apr. 23, 2014) — A Harvard University study suggests monkeys can use symbols to perform basic math calculations. Video provided by Newsy
Powered by NewsLook.com
Raw: Leopard Bites Man in India

Raw: Leopard Bites Man in India

AP (Apr. 22, 2014) — A leopard caused panic in the city of Chandrapur on Monday when it sprung from the roof of a house and charged at rescue workers. (April 22) Video provided by AP
Powered by NewsLook.com
Iowa College Finds Beauty in Bulldogs

Iowa College Finds Beauty in Bulldogs

AP (Apr. 22, 2014) — Drake University hosts 35th annual Beautiful Bulldog Contest. (April 21) Video provided by AP
Powered by NewsLook.com
805-Pound Shark Caught Off The Coast Of Florida

805-Pound Shark Caught Off The Coast Of Florida

Newsy (Apr. 22, 2014) — One Florida fisherman caught a 805-pound shark off the coast of Florida earlier this month. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins