Featured Research

from universities, journals, and other organizations

How healthy are you for your age?

Date:
May 22, 2013
Source:
Journal of Visualized Experiments (JOVE)
Summary:
A new technique measures the health of human genetic material in relation to a patient's age. This could lead to the use of a "genetic thermometer" to assess a patient's health in relation to other individuals of the same age.

New research published in Journal of Visualized Experiments (JoVE) describes a technique to measure the health of human genetic material in relation to a patient's age. The method is demonstrated by the laboratory of Dr. Gil Atzmon at New York's Albert Einstein College of Medicine. Dr. Atzmon hopes that the dissemination of this technique will lead to the development of a "genetic thermometer" to assess a patient's health in relation to other individuals of the same age.

Related Articles


The JoVE publication features a technique that measures telomere length. Recently, telomeres have gained attention because they serve as "caps" to chromosomes. As such, they mark the ends of genetic material and ensure that genes do not degrade as cells divide. Starting with the first replication of DNA and division of a fertilized egg, chromosomes shorten because the DNA replication process is imperfect. Certain organs, like the stomach or skin, are composed of tissues that reconstitute themselves frequently. In these organs, and in young individuals, the telomerase enzyme extends telomeres with each division, negating chromosomal shortening that would otherwise occur. Telomerase activity declines as people age, and as a result telomeres shorten and can be responsible for age related afflictions and some cancers. Overall health can impact how quickly these telomeres degrade.

"Think of telomere length as though it was a thermometer. It measures the health of your genetic material," Dr. Atzmon explains. "It tells you how fit you are in relation to the age you are. If you have longer telomeres you are in good shape, if you have shorter telomeres you are less fit for your age and are not in good health."

Dr. Atzmon hopes that publication of this article will impact the aging community by classifying health relative to an individual's age. "I published in JoVE because I want more people to use the technique. As we [the medical community] collect more data, we can build a better index of age and health by population, and more accurately place a patient on the right spot in a continuum."

Adoption of this technique will allow clinicians to monitor a patient's health as they are treated, by comparing telomere degradation of a sick patient to other patients with that disease and to determine if treatment is slowing degradation. Dr. Kira Henderson, JoVE Editor and Director of Review, explains, "Telomere length and telomerase function impacts several realms of biological and medical research- from preventative aging models to cancer treatments. Maintaining the telomere is a pre-requisite to extending life and improving long-term health. It is our hope that the application of this JoVE video-article will elucidate relationships between disease state and telomere function and encourage advancement in this important field of study."


Story Source:

The above story is based on materials provided by Journal of Visualized Experiments (JOVE). Note: Materials may be edited for content and length.


Journal References:

  1. Mary Derasmo Axelrad, Temuri Budagov, Gil Atzmon. Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence. Journal of Visualized Experiments, 2013; (75) DOI: 10.3791/50246
  2. Mary Derasmo Axelrad, Temuri Budagov, Gil Atzmon. Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence. Journal of Visualized Experiments, 2013; (75) DOI: 10.3791/50246

Cite This Page:

Journal of Visualized Experiments (JOVE). "How healthy are you for your age?." ScienceDaily. ScienceDaily, 22 May 2013. <www.sciencedaily.com/releases/2013/05/130522095333.htm>.
Journal of Visualized Experiments (JOVE). (2013, May 22). How healthy are you for your age?. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/2013/05/130522095333.htm
Journal of Visualized Experiments (JOVE). "How healthy are you for your age?." ScienceDaily. www.sciencedaily.com/releases/2013/05/130522095333.htm (accessed February 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, February 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Hikers Rescued After Fall from Oregon Mountain

Hikers Rescued After Fall from Oregon Mountain

AP (Feb. 1, 2015) Two climbers who were hurt in a fall on Mount Hood are now being treated for their injuries. Rescue officials say they were airlifted off the mountain Saturday afternoon by an Oregon National Guard helicopter. (Feb. 2) Video provided by AP
Powered by NewsLook.com
Smart Glasses Augment Reality to Help Visually Impaired

Smart Glasses Augment Reality to Help Visually Impaired

Reuters - Innovations Video Online (Feb. 1, 2015) New augmented reality smart glasses developed by researchers at Oxford University can help people with visual impairments improve their vision by providing depth-based feedback, allowing users to "see" better. Joel Flynn reports. Video provided by Reuters
Powered by NewsLook.com
Flu Season Hitting Elderly Hard

Flu Season Hitting Elderly Hard

Reuters - US Online Video (Jan. 31, 2015) The CDC says this year&apos;s flu season is hitting people 65 years of age and older especially hard. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins