Featured Research

from universities, journals, and other organizations

An altered gut microbiota can predict diabetes

Date:
June 3, 2013
Source:
University of Gothenburg
Summary:
Intestinal bacteria may have a greater influence on us than was previously thought. Researchers have shown that patients with type 2 diabetes have an altered gut microbiota. Their findings have led to a new model to identify patients at increased risk of developing diabetes.

Intestinal bacteria may have a greater influence on us than was previously thought. In a study published in the prestigious journal Nature on 29 May, researchers at the Sahlgrenska Academy and Chalmers University of Technology show that patients with type 2 diabetes have an altered gut microbiota. Their findings have led to a new model to identify patients at increased risk of developing diabetes.
Credit: Image courtesy of University of Gothenburg

Intestinal bacteria may have a greater influence on us than was previously thought. In a study published in the journal Nature on 29 May, researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden and Chalmers University of Technology, Sweden, show that patients with type 2 diabetes have an altered gut microbiota. Their findings have led to a new model to identify patients at increased risk of developing diabetes.

The human body contains ten times more bacteria than human cells. Most of these bacteria comprise the normal gut microbiota. Our bodies thus contain a vast number of bacterial genes in addition to the genes in our own cells, and are collectively known as the metagenome.

Three Swedish, Gothenburg-based research groups led by Fredrik Bäckhed and Björn Fagergberg, Sahlgrenska Academy, University of Gothenburg, and Jens Nielsen of Chalmers University of Technology compared the metagenome of 145 women with diabetes, impaired glucose tolerance and healthy controls, and showed that women with type 2 diabetes have an altered gut microbiota.

Furthermore, healthy women have higher numbers of gut bacteria known to be producers of butyrate, a fatty acid that has previously been linked to beneficial health effect.

On the basis of these findings, the researchers developed a new model that can distinguish between patients with type 2 diabetes and healthy women by analysis of the metagenome. This model has better predictive value than the classical predictive markers used today, such as body-mass index and waist-hip ratio.

"By examining the patient's gut microbiota, we could predict which patients are at risk of developing diabetes. The big challenge is to find out whether the composition of the gut microbiota promotes the onset of age-related diabetes. If this is the case, this would indicate new opportunities to prevent the disease," says Professor Fredrik Bäckhed.

"In this study, we have developed new methods to analyze the metagenomic data and have been able to exploit much more of the 'unknown' metagenome, that is, the bacteria that have not been previously mapped," continues Jens Nielsen, Professor of Systems Biology at Chalmers University of Technology. "The study is an excellent example of how novel technologies, developed in connection with Chalmers' initiative in life science, can assist in analyzing large amounts of data from the clinic."

The study Gut metagenome in European women with normal, impaired and diabetic glucose control was published in Nature on May 29.


Story Source:

The above story is based on materials provided by University of Gothenburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. Fredrik H. Karlsson, Valentina Tremaroli, Intawat Nookaew, Göran Bergström, Carl Johan Behre, Björn Fagerberg, Jens Nielsen, Fredrik Bäckhed. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature, 2013; DOI: 10.1038/nature12198

Cite This Page:

University of Gothenburg. "An altered gut microbiota can predict diabetes." ScienceDaily. ScienceDaily, 3 June 2013. <www.sciencedaily.com/releases/2013/06/130603092328.htm>.
University of Gothenburg. (2013, June 3). An altered gut microbiota can predict diabetes. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2013/06/130603092328.htm
University of Gothenburg. "An altered gut microbiota can predict diabetes." ScienceDaily. www.sciencedaily.com/releases/2013/06/130603092328.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) — The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) — The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) — Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com
Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) — Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins