Featured Research

from universities, journals, and other organizations

Stem cell study could aid quest to combat range of diseases

Date:
June 3, 2013
Source:
University of Edinburgh
Summary:
Scientists have taken a vital step forward in understanding how cells from skin tissue can be reprogrammed to become stem cells.

Scientists have taken a vital step forward in understanding how cells from skin tissue can be reprogrammed to become stem cells.

New research could pave the way to generate these stem cells efficiently to better understand and develop treatments for diseases such as multiple sclerosis, Parkinson's disease and muscular degeneration.

The study of how these cells -- known as induced pluripotent stem cells (iPSCs) -- were reprogramed was led by the University of Edinburgh and is published in the journal Nature.

Scientists found that the process by which iPSCs are created is not simply a reversal of how skin cells are generated in normal human development.

Researchers made the discovery by tracking the change of skin cells during the reprogramming process.

All cells in the human body begin life as a mass of cells, with the capacity to change into any specialised cell, such as skin or muscle cell.

By returning adult cells to this original state and recreating the cell type needed for treatment scientists hope to find ways of tackling diseases such as MS, in which cells become faulty and need to be replaced.

Scientists have been able to create stem cells in this way since 2006 but, until now, it has not been clear how adult cells 'forget' their specialised roles to be reprogrammed by scientists.

Experts say that current methods of iPSCs production are time consuming and costly. It takes around four weeks to make human stem cells and even then the process does not always work.

Researchers say that their new insight will enable them to streamline the stem cell production process. The finding may also shed light on how to create different cell types -- like muscle or brain cells -- that can be used to improve our understanding of diseases and treatment.

Dr Keisuke Kaji, of the Medical Research Council Centre for Regenerative Medicine at the University of Edinburgh, said: "As exciting as this technology is, we still know very little about how cell reprogramming actually works. Using a new technique, we have improved our understanding of the process. Our work marks an exciting step towards ensuring that induced pluripotent stem cells technology will meet its full potential."


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Journal Reference:

  1. James O’Malley, Stavroula Skylaki, Kumiko A. Iwabuchi, Eleni Chantzoura, Tyson Ruetz, Anna Johnsson, Simon R. Tomlinson, Sten Linnarsson, Keisuke Kaji. High-resolution analysis with novel cell-surface markers identifies routes to iPS cells. Nature, 2013; DOI: 10.1038/nature12243

Cite This Page:

University of Edinburgh. "Stem cell study could aid quest to combat range of diseases." ScienceDaily. ScienceDaily, 3 June 2013. <www.sciencedaily.com/releases/2013/06/130603113629.htm>.
University of Edinburgh. (2013, June 3). Stem cell study could aid quest to combat range of diseases. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2013/06/130603113629.htm
University of Edinburgh. "Stem cell study could aid quest to combat range of diseases." ScienceDaily. www.sciencedaily.com/releases/2013/06/130603113629.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins