Featured Research

from universities, journals, and other organizations

How do immune cells detect infections?

Date:
June 7, 2013
Source:
McGill University
Summary:
Researchers are using computer simulations to shed light on how immune cells may identify foreign antigens.

Immune T-cells have to distinguish foreign ligands (red) from self-ligands (green) using an internal biochemical toolbox.
Credit: Image courtesy of McGill University

How do immune cells manage to sort through vast numbers of similar-looking proteins within the body to detect foreign invaders and fight infections?

Related Articles


"For immune cells, singling out foreign proteins is like looking for a needle in a haystack -- where the needle may look very much like a straw, and where some straws may also look very much like a needle," notes McGill University physics professor Paul François.

Understanding how immune cells tackle this formidable challenge is important, because it could provide crucial insights into the understanding of immune diseases, from AIDS to auto-immune disorders.

In a study published May 21 in the journal Physical Review Letters, François and McGill graduate student Jean-Benoît Lalanne used computational tools to examine what kind of solutions immune systems may use to detect small concentrations of foreign antigens (characteristic of potentially harmful infections) in a sea of "self-antigens" normally present at the surface of cells.

The researchers' computer simulations yielded a surprisingly simple solution related to the well-known phenomenon of biochemical adaptation -- a general biochemical mechanism that enable organisms to cope with varying environmental conditions.

To find solutions, the computer uses an algorithm inspired by Darwinian evolution. This algorithm, designed previously within the François research group, randomly generates mathematical models of biochemical networks. It then scores them by comparing properties of these networks to predefined properties of the immune system. Networks with best scores are duplicated in the next generation and mutated, and the process is iterated over many simulated "generations" until networks reach a perfect score.

In this case, almost all solutions found were very similar, sharing a common core structure or motif.

"Our approach provides a simpler theoretical framework and understanding of what happens" as immune cells sort through the "haystack" to detect foreign antigens and trigger the immune response, François says. "Our model shares many similarities with real immune networks. Strikingly, the simplest evolved solution we found has both similar characteristics and some of the blind spots of real immune cells we studied in a previous collaborative study with the groups of Grégoire Altan-Bonnet (Memorial Sloane Kettering, New York), Eric Siggia (Rockefeller University, New York) and Massimo Vergassola (Pasteur Institute, Paris)."

Funding for the research was provided by the Natural Sciences and Engineering Research Council of Canada and the Human Frontier Science Program.


Story Source:

The above story is based on materials provided by McGill University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jean-Benoît Lalanne, Paul François. Principles of Adaptive Sorting Revealed by In Silico Evolution. Physical Review Letters, 2013; 110 (21) DOI: 10.1103/PhysRevLett.110.218102

Cite This Page:

McGill University. "How do immune cells detect infections?." ScienceDaily. ScienceDaily, 7 June 2013. <www.sciencedaily.com/releases/2013/06/130607130557.htm>.
McGill University. (2013, June 7). How do immune cells detect infections?. ScienceDaily. Retrieved January 26, 2015 from www.sciencedaily.com/releases/2013/06/130607130557.htm
McGill University. "How do immune cells detect infections?." ScienceDaily. www.sciencedaily.com/releases/2013/06/130607130557.htm (accessed January 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, January 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) — The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) — Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) — Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) — A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins