Featured Research

from universities, journals, and other organizations

Findings on onset of uterine fibroids provide potential for novel treatments

Date:
June 7, 2013
Source:
Academy of Finland
Summary:
Uterine leiomyomata, or fibroids, are benign tumors that nevertheless affect the health of millions of women. They may cause, for instance, pain, bleeding and infertility. Fibroids are also the most common reason for a hysterectomy. Now, scientists in Finland have identified the molecular mechanisms underlying the onset of common leiomyomata.

Uterine leiomyomata, or fibroids, are benign tumours that nevertheless affect the health of millions of women. They may cause, for instance, pain, bleeding and infertility. Fibroids are also the most common reason for a hysterectomy; for example, some 8,000 hysterectomies are made in Finland each year.

Scientists at the Academy of Finland's Centre of Excellence in Cancer Genetics Research have identified the molecular mechanisms underlying the onset of common leiomyomata. The results of their research were published in the top medical journal New England Journal of Medicine in early June.

"These new findings are essential for the further development of pharmacological treatments for this type of tumour," says Academy Professor Lauri Aaltonen, who heads the Centre the Excellence based at the University of Helsinki.

Aaltonen's team has demonstrated how the genome of benign uterine leiomyomata differs from normal uterine tissue. Very little was known about the aetiology of leiomyomata before the team's research. The team has previously identified a gene defect that explains more than half of these tumours. The present whole-genome sequencing proved that most of the rest of the tumours develop as a result of chromosome fragmentation and rearrangements.

"Complex chromosomal rearrangements are a major cause of cellular changes that contribute to the onset of benign uterine leiomyomata," Aaltonen states.

Similar changes resulting from chromosomal rearrangements are normally identified in malignant tumours. The results of Aaltonen's team suggest that the same mechanisms may also underlie the onset of non-cancerous tumours.

"Our research also indicates what mechanisms may prevent benign tumours from becoming malignant," Aaltonen adds.


Story Source:

The above story is based on materials provided by Academy of Finland. Note: Materials may be edited for content and length.


Journal Reference:

  1. Miika Mehine, Eevi Kaasinen, Netta Mäkinen, Riku Katainen, Kati Kämpjärvi, Esa Pitkänen, Hanna-Riikka Heinonen, Ralf Bützow, Outi Kilpivaara, Anna Kuosmanen, Heikki Ristolainen, Massimiliano Gentile, Jari Sjöberg, Pia Vahteristo, Lauri A. Aaltonen. Characterization of Uterine Leiomyomas by Whole-Genome Sequencing. New England Journal of Medicine, 2013; 130605140036002 DOI: 10.1056/NEJMoa1302736

Cite This Page:

Academy of Finland. "Findings on onset of uterine fibroids provide potential for novel treatments." ScienceDaily. ScienceDaily, 7 June 2013. <www.sciencedaily.com/releases/2013/06/130607130950.htm>.
Academy of Finland. (2013, June 7). Findings on onset of uterine fibroids provide potential for novel treatments. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2013/06/130607130950.htm
Academy of Finland. "Findings on onset of uterine fibroids provide potential for novel treatments." ScienceDaily. www.sciencedaily.com/releases/2013/06/130607130950.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) — The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) — A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) — The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) — The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins