Featured Research

from universities, journals, and other organizations

Naturally occurring hormone induces egg maturation

Date:
June 17, 2013
Source:
Endocrine Society
Summary:
The naturally occurring hormone kisspeptin effectively induces egg maturation during infertility treatment, according to a clinical in vitro fertilization (IVF) study.

The naturally occurring hormone kisspeptin effectively induces egg maturation during infertility treatment, according to a clinical in vitro fertilization (IVF) study.

The results were presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco.

Aptly named after the popular chocolate Hershey's kiss candy, kisspeptin was discovered in Hershey, PA, in 1996. Released by the brain in both males and females, the hormone triggers the development of secondary sexual characteristics and other changes of puberty.

Each year, thousands of women seek IVF treatment for infertility. The treatment is readily available and often successful, but, like all medical interventions, still has some risks. One of the most serious is a condition called ovarian hyperstimulation syndrome. This condition results when the hormones used to stimulate egg maturation overstimulate the ovaries, which can then become painfully swollen. Often cases are mild and improve without treatment in one to two weeks. However, approximately 10 percent of cases are severe ones causing life-threatening complications, including shortness of breath, blood clots and kidney failure.

In contrast, kisspeptin stimulates the ovaries to release levels of reproductive hormones that are similar to those produced naturally by women with normal menstrual cycles. Because of this, fertility researchers are interested in the hormone's potential to safely induce egg maturation in IVF.

Results from this study funded by the Medical Research Council UK and the National Institute for Health Research indicate that the hormone kisspeptin effectively induces egg maturation when used during IVF treatment. In 21 of 22 women who participated in the study, egg maturation occurred after kisspeptin injections. Embryos developed in 20 women. Twelve hours after kisspeptin injections, luteinizing hormone levels increased eightfold. During the normal reproductive cycle, luteinizing hormone increases to trigger ovulation.

"We have shown that kisspeptin can be used effectively in patients undergoing IVF treatment to more naturally stimulate the release of reproductive hormones and result in a healthy baby," said study lead author Waljit Dhillo, M.D., Ph.D., Professor of Endocrinology at Imperial College London, United Kingdom. "The use of a hormone that stimulates the release of reproductive hormones during IVF treatment as occurs in normal women could prevent ovarian hyperstimulation syndrome. Kisspeptin may, therefore, offer an entirely novel therapeutic option for fertility treatment."

Study participants included 22 women who received IVF treatment with kisspeptin in place of the customary hormone, human chorionic gonadotropin, used to induce egg maturation during IVF. Thirty-six hours after kisspeptin injection, investigators obtained the mature eggs, which they then artificially inseminated. After embryo development occurred, investigators transferred one to two embryos to the uterus.

While it is still too early to assess all of the pregnancy data, early data are very encouraging, showing that eight of 19 participants were pregnant 12 days after receiving an embryo transfer. One woman has already given birth to a healthy baby boy. The next step, according to Dhillo, is to determine whether kisspeptin can prevent ovarian hyperstimulation syndrome in women who are healthy, but infertile.

The Medical Research Council UK and the National Institute for Health Research funded the study.


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

Endocrine Society. "Naturally occurring hormone induces egg maturation." ScienceDaily. ScienceDaily, 17 June 2013. <www.sciencedaily.com/releases/2013/06/130617142035.htm>.
Endocrine Society. (2013, June 17). Naturally occurring hormone induces egg maturation. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2013/06/130617142035.htm
Endocrine Society. "Naturally occurring hormone induces egg maturation." ScienceDaily. www.sciencedaily.com/releases/2013/06/130617142035.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins