Featured Research

from universities, journals, and other organizations

Naturally occurring hormone induces egg maturation

Date:
June 17, 2013
Source:
Endocrine Society
Summary:
The naturally occurring hormone kisspeptin effectively induces egg maturation during infertility treatment, according to a clinical in vitro fertilization (IVF) study.

The naturally occurring hormone kisspeptin effectively induces egg maturation during infertility treatment, according to a clinical in vitro fertilization (IVF) study.

The results were presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco.

Aptly named after the popular chocolate Hershey's kiss candy, kisspeptin was discovered in Hershey, PA, in 1996. Released by the brain in both males and females, the hormone triggers the development of secondary sexual characteristics and other changes of puberty.

Each year, thousands of women seek IVF treatment for infertility. The treatment is readily available and often successful, but, like all medical interventions, still has some risks. One of the most serious is a condition called ovarian hyperstimulation syndrome. This condition results when the hormones used to stimulate egg maturation overstimulate the ovaries, which can then become painfully swollen. Often cases are mild and improve without treatment in one to two weeks. However, approximately 10 percent of cases are severe ones causing life-threatening complications, including shortness of breath, blood clots and kidney failure.

In contrast, kisspeptin stimulates the ovaries to release levels of reproductive hormones that are similar to those produced naturally by women with normal menstrual cycles. Because of this, fertility researchers are interested in the hormone's potential to safely induce egg maturation in IVF.

Results from this study funded by the Medical Research Council UK and the National Institute for Health Research indicate that the hormone kisspeptin effectively induces egg maturation when used during IVF treatment. In 21 of 22 women who participated in the study, egg maturation occurred after kisspeptin injections. Embryos developed in 20 women. Twelve hours after kisspeptin injections, luteinizing hormone levels increased eightfold. During the normal reproductive cycle, luteinizing hormone increases to trigger ovulation.

"We have shown that kisspeptin can be used effectively in patients undergoing IVF treatment to more naturally stimulate the release of reproductive hormones and result in a healthy baby," said study lead author Waljit Dhillo, M.D., Ph.D., Professor of Endocrinology at Imperial College London, United Kingdom. "The use of a hormone that stimulates the release of reproductive hormones during IVF treatment as occurs in normal women could prevent ovarian hyperstimulation syndrome. Kisspeptin may, therefore, offer an entirely novel therapeutic option for fertility treatment."

Study participants included 22 women who received IVF treatment with kisspeptin in place of the customary hormone, human chorionic gonadotropin, used to induce egg maturation during IVF. Thirty-six hours after kisspeptin injection, investigators obtained the mature eggs, which they then artificially inseminated. After embryo development occurred, investigators transferred one to two embryos to the uterus.

While it is still too early to assess all of the pregnancy data, early data are very encouraging, showing that eight of 19 participants were pregnant 12 days after receiving an embryo transfer. One woman has already given birth to a healthy baby boy. The next step, according to Dhillo, is to determine whether kisspeptin can prevent ovarian hyperstimulation syndrome in women who are healthy, but infertile.

The Medical Research Council UK and the National Institute for Health Research funded the study.


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

Endocrine Society. "Naturally occurring hormone induces egg maturation." ScienceDaily. ScienceDaily, 17 June 2013. <www.sciencedaily.com/releases/2013/06/130617142035.htm>.
Endocrine Society. (2013, June 17). Naturally occurring hormone induces egg maturation. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2013/06/130617142035.htm
Endocrine Society. "Naturally occurring hormone induces egg maturation." ScienceDaily. www.sciencedaily.com/releases/2013/06/130617142035.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins