Featured Research

from universities, journals, and other organizations

Molecule considered to be a breast cancer indicator also has a protective function

Date:
June 25, 2013
Source:
Centre for Genomic Regulation
Summary:
One of the main indicators for determining the activity of a tumor or cancer is cell division. Cancer cells divide more than other types and the genes and molecules involved in the process of division are, often, targets for identifying and treating certain types of cancer. Researchers have now revealed that one of these molecules (PLK1 kinase), up to now thought to be related to cancer, can also be crucial for the proper functioning of the cell.

One of the main indicators for determining the activity of a tumour or cancer is cell division. Cancer cells divide more than other types and the genes and molecules involved in the process of division are, often, targets for identifying and treating certain types of cancer.

Researchers from the Centre for Genomic Regulation led by Miguel Beato have, in an article published in the journal Cell Reports, just revealed that one of these molecules (PLK1 kinase), up to now thought to be related to cancer, can also be crucial for the proper functioning of the cell.

PLK1 had always been associated with breast cancer due to its role in cell division. It is an enzyme that is very active during the cell cycle, in particular during the replication of genetic material and mitosis. That is why it is found in large amounts in cells affected by cancer. Now, Beato and his collaborators have observed that PLK1 also plays an important role in the regulation of genes activated during the resting stage and the initiation of division.

"What we have seen using genomics and proteomics techniques is that when PLK1 is expressed in the correct amounts it participates in the response to oestrogen and is needed to control and regulate the genes that stop cell division," explains Miguel Beato, head of the Chromatin and Gene Expression group at the Centre for Genomic Regulation. "Our work demonstrates that PKL is not always an indicator of poor prognosis. It is important that we learn to use this information and, when we design breast cancer treatments, take into account the fact that we need only reduce high levels of PLK1, which could be harmful, and try to maintain the physiological levels," he adds.

This work has been possible thanks to data on breast cancer patients and has been conducted entirely in the Centre for Genomic Regulation in Barcelona.


Story Source:

The above story is based on materials provided by Centre for Genomic Regulation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Michael Wierer, Gaetano Verde, Paola Pisano, Henrik Molina, Jofre Font-Mateu, Luciano DiCroce, Miguel Beato. PLK1 Signaling in Breast Cancer Cells Cooperates with Estrogen Receptor-Dependent Gene Transcription. Cell Reports, 2013; DOI: 10.1016/j.celrep.2013.05.024

Cite This Page:

Centre for Genomic Regulation. "Molecule considered to be a breast cancer indicator also has a protective function." ScienceDaily. ScienceDaily, 25 June 2013. <www.sciencedaily.com/releases/2013/06/130625091858.htm>.
Centre for Genomic Regulation. (2013, June 25). Molecule considered to be a breast cancer indicator also has a protective function. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2013/06/130625091858.htm
Centre for Genomic Regulation. "Molecule considered to be a breast cancer indicator also has a protective function." ScienceDaily. www.sciencedaily.com/releases/2013/06/130625091858.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins