Featured Research

from universities, journals, and other organizations

Molecule considered to be a breast cancer indicator also has a protective function

Date:
June 25, 2013
Source:
Centre for Genomic Regulation
Summary:
One of the main indicators for determining the activity of a tumor or cancer is cell division. Cancer cells divide more than other types and the genes and molecules involved in the process of division are, often, targets for identifying and treating certain types of cancer. Researchers have now revealed that one of these molecules (PLK1 kinase), up to now thought to be related to cancer, can also be crucial for the proper functioning of the cell.

One of the main indicators for determining the activity of a tumour or cancer is cell division. Cancer cells divide more than other types and the genes and molecules involved in the process of division are, often, targets for identifying and treating certain types of cancer.

Researchers from the Centre for Genomic Regulation led by Miguel Beato have, in an article published in the journal Cell Reports, just revealed that one of these molecules (PLK1 kinase), up to now thought to be related to cancer, can also be crucial for the proper functioning of the cell.

PLK1 had always been associated with breast cancer due to its role in cell division. It is an enzyme that is very active during the cell cycle, in particular during the replication of genetic material and mitosis. That is why it is found in large amounts in cells affected by cancer. Now, Beato and his collaborators have observed that PLK1 also plays an important role in the regulation of genes activated during the resting stage and the initiation of division.

"What we have seen using genomics and proteomics techniques is that when PLK1 is expressed in the correct amounts it participates in the response to oestrogen and is needed to control and regulate the genes that stop cell division," explains Miguel Beato, head of the Chromatin and Gene Expression group at the Centre for Genomic Regulation. "Our work demonstrates that PKL is not always an indicator of poor prognosis. It is important that we learn to use this information and, when we design breast cancer treatments, take into account the fact that we need only reduce high levels of PLK1, which could be harmful, and try to maintain the physiological levels," he adds.

This work has been possible thanks to data on breast cancer patients and has been conducted entirely in the Centre for Genomic Regulation in Barcelona.


Story Source:

The above story is based on materials provided by Centre for Genomic Regulation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Michael Wierer, Gaetano Verde, Paola Pisano, Henrik Molina, Jofre Font-Mateu, Luciano DiCroce, Miguel Beato. PLK1 Signaling in Breast Cancer Cells Cooperates with Estrogen Receptor-Dependent Gene Transcription. Cell Reports, 2013; DOI: 10.1016/j.celrep.2013.05.024

Cite This Page:

Centre for Genomic Regulation. "Molecule considered to be a breast cancer indicator also has a protective function." ScienceDaily. ScienceDaily, 25 June 2013. <www.sciencedaily.com/releases/2013/06/130625091858.htm>.
Centre for Genomic Regulation. (2013, June 25). Molecule considered to be a breast cancer indicator also has a protective function. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2013/06/130625091858.htm
Centre for Genomic Regulation. "Molecule considered to be a breast cancer indicator also has a protective function." ScienceDaily. www.sciencedaily.com/releases/2013/06/130625091858.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins