Featured Research

from universities, journals, and other organizations

Using computer models to predict more effective therapies for colon tumors

Date:
June 27, 2013
Source:
Charité - Universitätsmedizin Berlin
Summary:
Scientist have used a computer simulation for predicting the effectiveness of various combination therapies for colon tumors.

Scientist at Charité -- Universitätsmedizin Berlin have used a computer simulation for predicting the effectiveness of various combination therapies for colon tumors. The study has been published in the current issue of the professional journal Molecular Systems Biology.

In most tumors, the communication between the individual cells is disturbed and the cells permanently receive growth and survival signals. For this reason, drugs are increasingly used in modern tumor therapy that targets those molecules to shut down these faulty signals. Hitherto, however, it has been difficult to predict the success of such a therapy, since the signal molecules are integrated into an extremely complex cellular network, which, moreover, reacts differently for each patient, depending on the mutations the tumor bears.

The research group headed by Nils Blüthgen, Charité Institute of Pathology, has now examined how the interconnection of such a cellular network affects the effectiveness of a therapy. For this purpose, the scientists created computer models to simulate the networks of various colon cancer cells. The models were adapted to quantitative data from cell culture experiments. When analyzing their computer simulations, the researchers discovered that the cellular tumor networks exhibited strong feedback characteristics. This means that the cutting off of a particular signal molecule activates a receptor, which, in turn, then switches on signal paths that favor the survival of the tumor cell. In a further step, the computer model predicted a combination therapy using two drugs, which prevents the activation of survival signals, so making for a more effective therapy. The scientists have tested these predictions on various cell models. "The remarkable thing is that the combination of two therapies is effective with a large number of different mutations, including the mutant oncogene KRAS. This is a gene, which is of key importance for the regulation of growth and differentiation processes, and for which no targeted therapy has been possible up to now," stated Nils Blüthgen. "However, it is still too early to say whether this behavior detected in the cell culture model can be applied to patients. Here, further investigations are necessary."

This approach undertaken by the researchers to combine computer models with quantitative data to simulate the behavior of networks is called system biology. It is considered a promising method of examining therapies and diagnostics for complex diseases. "Particularly when investigating the effect of inhibitors in complex networks, it is hardly possible to predict the network's response without the use of computer models," according to Blüthgen.


Story Source:

The above story is based on materials provided by Charité - Universitätsmedizin Berlin. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bertram Klinger, Anja Sieber, Raphaela Fritsche-Guenther, Franziska Witzel, Leanne Berry, Dirk Schumacher, Yibing Yan, Pawel Durek, Mark Merchant, Reinhold Schäfer, Christine Sers, Nils Blüthgen. Network quantification of EGFR signaling unveils potential for targeted combination therapy. Molecular Systems Biology, 2013; 9 DOI: 10.1038/msb.2013.29

Cite This Page:

Charité - Universitätsmedizin Berlin. "Using computer models to predict more effective therapies for colon tumors." ScienceDaily. ScienceDaily, 27 June 2013. <www.sciencedaily.com/releases/2013/06/130627083158.htm>.
Charité - Universitätsmedizin Berlin. (2013, June 27). Using computer models to predict more effective therapies for colon tumors. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2013/06/130627083158.htm
Charité - Universitätsmedizin Berlin. "Using computer models to predict more effective therapies for colon tumors." ScienceDaily. www.sciencedaily.com/releases/2013/06/130627083158.htm (accessed April 19, 2014).

Share This



More Computers & Math News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Man Claims He Found Loch Ness Monster With... Apple Maps?

Man Claims He Found Loch Ness Monster With... Apple Maps?

Newsy (Apr. 18, 2014) — Andy Dixon showed the Daily Mail a screenshot of what he believes to be the mythical beast swimming just below the lake's surface. Video provided by Newsy
Powered by NewsLook.com
Facebook Announces Location-Sharing Feature 'Nearby Friends'

Facebook Announces Location-Sharing Feature 'Nearby Friends'

Newsy (Apr. 18, 2014) — Facebook's pending Nearby Friends feature will give users the option to share their nonspecific or specific locations with certain friends. Video provided by Newsy
Powered by NewsLook.com
Michaels Hack Compromises About 3 Million Credit Cards

Michaels Hack Compromises About 3 Million Credit Cards

Newsy (Apr. 18, 2014) — Michaels is now confirming that an eight-month security breach compromised about 3 million customers' credit and debit card data. Video provided by Newsy
Powered by NewsLook.com
Twitter Introduces Facebook-Style App Install Ads

Twitter Introduces Facebook-Style App Install Ads

Newsy (Apr. 17, 2014) — Twitter hopes to make money on app install ads, which has proven to be a successful strategy for Facebook. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins