Featured Research

from universities, journals, and other organizations

Type 1 diabetes: Can insulin-producing cells be regenerated?

Date:
June 27, 2013
Source:
INSERM (Institut national de la santé et de la recherche médicale)
Summary:
Scientists have published new results concerning type I diabetes. Researchers have shown that in mice, the pancreas contains cells capable of being converted into insulin-producing cells, something that can be done at any age.

Patrick Collombat, Inserm Research Director and head of the Avenir team at the Institut de Biologie Valrose in Nice, has published new results concerning Type I diabetes. Researchers show that, in mice, the pancreas contains cells capable of being converted into insulin-producing β cells, something that can be done at any age. They also demonstrate that all pancreatic β cells can be regenerated several times and that chemically-induced diabetes in mice can thus be "treated" repeatedly. The challenge for the researchers is now to show that these procedures can be applied to humans.

This work is published online in the Developmental Cell journal dated 27 June 2013.

Type I diabetes, characterised by the selective loss of pancreatic, insulin-producing β cells, is a condition that affects more than 30 million people worldwide. Despite current treatments, type I diabetic patients have a life expectancy that is reduced by five to eight years. It is in this context that the Avenir "Diabetes Genetics" team have been working to develop new approaches designed to regenerate these cells.

In 2009, researchers at the Valrose Biology Institute (Inserm/University Nice Sophia Antipolis) managed to convert glucagon-producing α cells into β cells in young mice. Today, thanks to the use of transgenic mice, they report the mechanisms resulting in this exchange of cell identity. Specifically, they show that pancreatic ductal cells can be continuously mobilised and literally transformed into α and subsequently into β cells, a process that works at any age. Such transformation is obtained through the forced activation of the Pax4 gene in the α cells of the pancreas. The resulting cascade of events causes the generation of brand-new β cells, thanks to the reactivation of development genes. Throughout this process, α cells are regenerated and gradually adopt the profile of β cells. This means that the pancreas has a virtually inexhaustible source of cells capable of replacing the β cells.

β cell regeneration in the pancreas

By artificially inducing type I diabetes in mice, "we also show that all the pancreatic β cells can be regenerated at least three times using this mechanism. Diabetes, induced in this way, in the mouse, can be literally "treated" multiple times thanks to the new stock of functional, insulin-producing β cells" explains Patrick Collombat, Inserm research director and principal author of the study.

These promising results obtained in the mouse suggest that the pancreas contains cells that can regenerate several times those β cells lost in type I diabetics.

"We are currently working on the possibility of inducing such regeneration by using pharmacological molecules. Thanks to this new data, we shall be concentrating in future years on determining whether these processes can also be made to work in humans, a real challenge in offering better treatments for type I diabetic patients," he concludes.


Story Source:

The above story is based on materials provided by INSERM (Institut national de la santé et de la recherche médicale). Note: Materials may be edited for content and length.


Journal Reference:

  1. Keith Al-Hasani, Anja Pfeifer, Monica Courtney, Nouha Ben-Othman, Elisabet Gjernes, Andhira Vieira, Noémie Druelle, Fabio Avolio, Philippe Ravassard, Gunter Leuckx, Sandra Lacas-Gervais, Damien Ambrosetti, Emmanuel Benizri, Jacob Hecksher-Sorensen, Pierre Gounon, Jorge Ferrer, Gerard Gradwohl, Harry Heimberg, Ahmed Mansouri, Patrick Collombat. Adult Duct-Lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes. Developmental Cell, 2013; DOI: 10.1016/j.devcel.2013.05.018

Cite This Page:

INSERM (Institut national de la santé et de la recherche médicale). "Type 1 diabetes: Can insulin-producing cells be regenerated?." ScienceDaily. ScienceDaily, 27 June 2013. <www.sciencedaily.com/releases/2013/06/130627131832.htm>.
INSERM (Institut national de la santé et de la recherche médicale). (2013, June 27). Type 1 diabetes: Can insulin-producing cells be regenerated?. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2013/06/130627131832.htm
INSERM (Institut national de la santé et de la recherche médicale). "Type 1 diabetes: Can insulin-producing cells be regenerated?." ScienceDaily. www.sciencedaily.com/releases/2013/06/130627131832.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Might Not Be Out Of Control In U.S., But Coverage Is

Ebola Might Not Be Out Of Control In U.S., But Coverage Is

Newsy (Oct. 2, 2014) — Coverage of the lone Ebola patient discovered in Texas has U.S. media in a frenzy — but does the coverage match the reality? Video provided by Newsy
Powered by NewsLook.com
Rhode Island Child With Enterovirus Dies After Infection

Rhode Island Child With Enterovirus Dies After Infection

Reuters - US Online Video (Oct. 2, 2014) — A Rhode Island child hospitalized with Enterovirus D68 has died of a bacterial infection, in what state public health officials say was an unusual and dangerous combination. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
US Hunts Contacts of Ebola Patient, Including Children

US Hunts Contacts of Ebola Patient, Including Children

AFP (Oct. 2, 2014) — Health officials in Texas on Wednesday scoured the Dallas area for people, including schoolchildren, who came in contact with a Liberian man who was diagnosed with Ebola in the United States. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Study Says Losing Sense Of Smell Can Indicate Death

Study Says Losing Sense Of Smell Can Indicate Death

Newsy (Oct. 2, 2014) — Researchers found elderly adults with a poor sense of smell are more likely to die within five years. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins