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Liver protein crucial for pregnancy

Date:
June 30, 2013
Source:
Universite de Montreal
Summary:
A protein first shown to function in the liver plays a crucial role in pregnancy in mice and has a key role in the human menstrual cycle, according to researchers.

A protein first shown to function in the liver plays a crucial role in pregnancy in mice and has a key role in the human menstrual cycle, according to researchers at the University of Montreal. Mice that were genetically engineered not to produce the liver receptor homolog-1 (Lrh-1) molecule were unable to create the uterine conditions necessary for establishing and sustaining pregnancy, resulting in the formation of defective placentas. The researchers then showed that Lhr-1 was present in the human uterus and the essential processes related to the success of early gestation.

"We previously showed that Lrh-1 is essential for ovulation. Our newest studies have revealed that it is plays an important role in the uterus, raising the possibility that Lrh-1 deficiency contributes to human gestational failure," explained lead author Bruce Murphy, of the university's Animal Reproduction Research Centre. "We worked with mice before looking at human tissues. I believe it premature to propose determination of Lrh-1 in uterine biopsies as a diagnostic tool, but we are working on determining the receptor's pattern of expression across the menstrual cycle."

The researchers also looked at whether hormone replacement therapy might restore normal uterine functions in the mice. "Progesterone did not make a difference. Although hormone therapy allowed for the embryos to implant, we saw problems with the lining in the uterus, compromised formation of the placenta, fetal growth retardation and fetal death," Murphy said. "However, there are new Lrh-1 agonists and antagonists, currently in clinical trials to treat hepatic consequences of type II diabetes, and thus therapeutic intervention might be possible."

The study was published in Nature Medicine on June 30, 2013, and was funded by the Canadian Institutes of Health Research. The US National Institutes of Health funded collaborators at Baylor University that contributed to the study.


Story Source:

The above story is based on materials provided by Universite de Montreal. Note: Materials may be edited for content and length.


Cite This Page:

Universite de Montreal. "Liver protein crucial for pregnancy." ScienceDaily. ScienceDaily, 30 June 2013. <www.sciencedaily.com/releases/2013/06/130630144447.htm>.
Universite de Montreal. (2013, June 30). Liver protein crucial for pregnancy. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2013/06/130630144447.htm
Universite de Montreal. "Liver protein crucial for pregnancy." ScienceDaily. www.sciencedaily.com/releases/2013/06/130630144447.htm (accessed September 17, 2014).

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