Featured Research

from universities, journals, and other organizations

Hippo pathway to better cancer treatment? Unusual key to regulating cell growth

Date:
July 11, 2013
Source:
University of British Columbia
Summary:
Researchers have discovered a potential new pathway to treat cancer by asking some odd questions about the size of animals.

Researchers at the University of British Columbia have discovered a potential new pathway to treat cancer by asking some odd questions about the size of animals.

"Mammals display a huge range in size from the largest blue whale to the tiniest fruit bat," says Colby Zaph, assistant professor of Pathology and Laboratory Medicine at the Biomedical Research Centre, who co-authored the study published in Developmental Cell.

"So why don't we have miniature whales or gigantic bats? It turns out that there are specific pathways that tell cells when to grow and when to stop."

One of those pathways is called the Hippo pathway -- a key control in how our organs are perfectly suited to our bodies, despite differences in size. Zaph, along with postdoctoral research fellow Menno Oudhoff, uncovered that size differences could be manipulated after a specific chemical modification called methylation dramatically affected its function.

Using mice genetically lacking an enzyme called Set7, the results show that methylation of a protein called Yap is critical for the function of the Hippo pathway. Loss of the Set7 enzyme resulted in cell growth and larger organs.

"It's too early to tell how successful modifying this pathway could be in terms of helping with treatment of cancer. But based on our results, drugs that may activate the Set7 enzyme -- to stop cell growth -- may be invaluable to fighting cancers with Hippo pathway mutations" says Zaph.

The pathway has gone relatively unchanged despite evolution and could play a crucial role in regenerative medicine, including in skin growth and liver regeneration.

"Harnessing these results to treat diseases is now the next step."


Story Source:

The above story is based on materials provided by University of British Columbia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Menno J. Oudhoff, Spencer A. Freeman, Amber L. Couzens, Frann Antignano, Ekaterina Kuznetsova, Paul H. Min, Jeffrey P. Northrop, Bernhard Lehnertz, Dalia Barsyte-Lovejoy, Masoud Vedadi, Cheryl H. Arrowsmith, Hiroshi Nishina, Michael R. Gold, Fabio M.V. Rossi, Anne-Claude Gingras, Colby Zaph. Control of the Hippo Pathway by Set7-Dependent Methylation of Yap. Developmental Cell, 2013; DOI: 10.1016/j.devcel.2013.05.025

Cite This Page:

University of British Columbia. "Hippo pathway to better cancer treatment? Unusual key to regulating cell growth." ScienceDaily. ScienceDaily, 11 July 2013. <www.sciencedaily.com/releases/2013/07/130711135308.htm>.
University of British Columbia. (2013, July 11). Hippo pathway to better cancer treatment? Unusual key to regulating cell growth. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2013/07/130711135308.htm
University of British Columbia. "Hippo pathway to better cancer treatment? Unusual key to regulating cell growth." ScienceDaily. www.sciencedaily.com/releases/2013/07/130711135308.htm (accessed September 2, 2014).

Share This




More Plants & Animals News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) — The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Sharks Off the Menu and on the Tourist Trail in Palau

Sharks Off the Menu and on the Tourist Trail in Palau

AFP (Sep. 2, 2014) — Tourists in Palau clamour to dive with sharks thanks to a pioneering conservation initiative -- as the island nation plans to completely ban commercial fishing in its vast ocean territory. 01:15 Video provided by AFP
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) — A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Coffee Then Napping: The (New) Key To Alertness

Coffee Then Napping: The (New) Key To Alertness

Newsy (Aug. 30, 2014) — Researchers say having a cup of coffee then taking a nap is more effective than a nap or coffee alone. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins