Featured Research

from universities, journals, and other organizations

World's first IVF baby born after preimplantation genome sequencing is now 11 months old

Date:
July 22, 2013
Source:
BGI Shenzhen
Summary:
The world's first IVF baby born after preimplantation genome sequencing is now 11 months old.

The largest genomic institute of the world, BGI Shenzhen, China (hereinafter BGI), together with Reproductive & Genetic Hospital CITIC-XIANGYA (hereinafter CITIC-XIANGYA) announced today that they have successfully applied Next Generation Sequencing (NGS) to detect in vitro fertilized (IVF) embryos with genetic abnormalities. The successful application of preimplantation sequencing (the most advanced form of preimplantation genetic screening, PGS) opens a new chapter in the field of human assisted reproduction, providing new hopes for IVF couples.

In preimplantation sequencing, 7 to 12 cells are removed from morphologically normal human embryos 5 days after fertilization in vitro. Embryos are subsequently cryopreserved by vitrification, and samples are analyzed by using the latest DNA technologies to detect abnormalities. Only genetically intact embryos are transferred to the uterus during the subsequent cycle, with minimal or no hormonal stimulation.

Since 2010, as a result of collaboration between BGI and CITIC-XIANGYA, sequenced embryos from 33 couples were transferred, and 22 pregnancies were achieved. The success rate was 66.7%. Up to now, 17 healthy babies were born.

On August 24, 2012, the world's first IVF baby sequenced before implantation was born in Hunan Province, China. Five days after fertilization in vitro, 7 embryos were biopsied and all samples were shipped to BGI for preimplantation sequencing. Based on a combination of NGS and bioinformatics analysis, 3 embryos were found to have normal chromosomal content and two of them were selected for transfer resulting in pregnancy. The baby is now 11 months old, healthy and developing normally.

On the 29th Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE) London, 7-11 July, 2013, research findings of BGI and CITIC- XIANGYA were presented in the lecture of Dr. Jian Li and colleagues from BGI, creating considerable acknowledgement among experts worldwide. In the next talk, Dr. Dagan Wells and colleagues from Oxford University announced the birth of the first IVF baby of the Western Hemisphere after genomic sequencing in England.

Professor Guangxiu Lu, President of CITIC XIANGYA and one of the founders and pioneers in human assisted reproduction in China called the birth as a landmark event in human IVF. As sequencing is the most accurate method for detection of genetic anomalies, doctors can transfer the best embryos of the cohort, this way pregnancy rates may be increased and the chance of abnormalities of genetic origin decreased.

Dr. Yutao Du, Vice-President of BGI Health Group said that with the introduction of new procedures, the cost of sequencing has decreased dramatically. Accordingly, preimplantation sequencing will become a choice for more and more IVF couples. The accuracy is increasing continuously, and new bioinformatic analysis approaches enable scientists to detect specific genetic disorders, even from single cells. Accordingly, preimplantation sequencing may have a crucial role in improving the efficiency and safety of human assisted reproduction.


Story Source:

The above story is based on materials provided by BGI Shenzhen. Note: Materials may be edited for content and length.


Cite This Page:

BGI Shenzhen. "World's first IVF baby born after preimplantation genome sequencing is now 11 months old." ScienceDaily. ScienceDaily, 22 July 2013. <www.sciencedaily.com/releases/2013/07/130722111416.htm>.
BGI Shenzhen. (2013, July 22). World's first IVF baby born after preimplantation genome sequencing is now 11 months old. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2013/07/130722111416.htm
BGI Shenzhen. "World's first IVF baby born after preimplantation genome sequencing is now 11 months old." ScienceDaily. www.sciencedaily.com/releases/2013/07/130722111416.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Ebola Patient Told Hospital He Was from Liberia

Ebola Patient Told Hospital He Was from Liberia

AP (Oct. 1, 2014) The first Ebola patient diagnosed in the U.S. initially went to a Dallas emergency room last week but was sent home, despite telling a nurse that he had been in disease-ravaged West Africa, the hospital acknowledged Wednesday. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins