Featured Research

from universities, journals, and other organizations

Laser-controlled molecular switch turns blood clotting on, off on command

Date:
July 24, 2013
Source:
Public Library of Science
Summary:
Researchers have designed tiny, light-controlled gold particles that can release DNA controls to switch blood clotting off and on.

DNA-controlled nanoparticles work as a two-way switch for blood clotting.
Credit: Helena de Puig

Researchers have designed tiny, light-controlled gold particles that can release DNA controls to switch blood clotting off and on.

The results are reported July 24 in the open access journal PLOS ONE by Kimberly Hamad-Schifferli and colleagues from the Massachusetts Institute of Technology.

The two-way switch for blood clotting relies on the ability of two gold nanoparticles to selectively release different DNA molecules from their surface under different wavelengths of laser excitation. When stimulated by one wavelength, one nanorod releases a piece of DNA that binds the blood protein thrombin and blocks clot formation. When the complementary DNA piece is released from the other nanorod, it acts as an antidote and releases thrombin, restoring clotting activity.

Natural blood clotting is precisely synchronized to occur at the right time and place. Wound healing, surgery and other conditions require manipulation of this process, typically through the use of anticoagulants like heparin or warfarin. However, these drugs are inherently one-sided as they can only block clotting, and reversing their effects depends on removing them from the bloodstream. The methods described in this research open up new possibilities for more precise, selective control of the blood clotting process during therapy.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Helena de Puig, Anna Cifuentes Rius, Dorma Flemister, Salmaan H. Baxamusa, Kimberly Hamad-Schifferli. Selective Light-Triggered Release of DNA from Gold Nanorods Switches Blood Clotting On and Off. PLoS ONE, 2013; 8 (7): e68511 DOI: 10.1371/journal.pone.0068511

Cite This Page:

Public Library of Science. "Laser-controlled molecular switch turns blood clotting on, off on command." ScienceDaily. ScienceDaily, 24 July 2013. <www.sciencedaily.com/releases/2013/07/130724200416.htm>.
Public Library of Science. (2013, July 24). Laser-controlled molecular switch turns blood clotting on, off on command. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2013/07/130724200416.htm
Public Library of Science. "Laser-controlled molecular switch turns blood clotting on, off on command." ScienceDaily. www.sciencedaily.com/releases/2013/07/130724200416.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins