Featured Research

from universities, journals, and other organizations

Not only bone density, but also quality of bone predicts fracture risk

Date:
August 5, 2013
Source:
University of Eastern Finland
Summary:
In a new study, bone histomorphometry and infrared spectroscopy revealed abnormal bone properties in children with vertebral fractures and in children after solid organ transplantation. Bone compositional changes in children with vertebral fractures and after different types of organ transplantation have not been reported previously.

Bone histomorphometry. Mineralized bone tissue is recognised as green trabeculaes. Newly formed, unmineralized bone tissue, i.e. osteoid, is seen as red seams on top of the mineralized bone tissue. Bone marrow is located between the bone trabeculae. Masson Goldner trichrome stain. Magnification 100x.
Credit: Image courtesy of University of Eastern Finland

In a study carried out at the University of Eastern Finland, bone histomorphometry and infrared spectroscopy revealed abnormal bone properties in children with vertebral fractures and in children after solid organ transplantation. Bone compositional changes in children with vertebral fractures and after different types of organ transplantation have not been reported previously.

Bone samples were investigated using bone histomorphometry, a microscopic method that provides information about bone metabolism and remodelling. In children with vertebral fractures, there were changes in bone composition, such as lower carbonate-to-phosphate-ratio and increased collagen maturity, which could explain the increased fracture risk. The results also suggest that in children who have undergone kidney, liver or heart transplantation, the various changes related to bone microarchitecture and turnover may be more important predictors of fracture risk than lowered bone mineral density alone. Early detection of such changes in bone quality could help prevent fractures.

Osteoporosis is the most common metabolic bone disease characterized by abnormal bone formation and resorption which lead to increased risk of bone fractures. However, the present diagnostics based on the measurement of bone mineral density predict fractures only moderately. In addition to decreased bone mineral density, changes in bone quality could explain increased fragility related to osteoporosis. The present study confirmed that bone histomorphometry is needed in clinical practice to study remodelling balance in bone in certain patient groups.

"Especially in clinically challenging scenarios where different treatment options are being considered, bone histomorphometry provides valuable information. An accurate diagnosis and choice of medication are especially important when treating paediatric patients," says Ms Inari Tamminen, MD, whose doctoral thesis on the topic was published in June.

The findings were originally published in Journal of Bone and Mineral Research and Journal of Bone and Mineral Metabolism.

The histomorphometry laboratory at the University of Eastern Finland in Kuopio is one of the few in the world analyzing clinical bone biopsies. More than 70 patient samples are analyzed annually. Over 30 years of expertise in quantitative histomorphometry have formed a solid basis for high quality research. Recent projects focus on paediatric patients with osteoporosis, genetic disorders and insufficiency fractures.


Story Source:

The above story is based on materials provided by University of Eastern Finland. Note: Materials may be edited for content and length.


Cite This Page:

University of Eastern Finland. "Not only bone density, but also quality of bone predicts fracture risk." ScienceDaily. ScienceDaily, 5 August 2013. <www.sciencedaily.com/releases/2013/08/130805092634.htm>.
University of Eastern Finland. (2013, August 5). Not only bone density, but also quality of bone predicts fracture risk. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2013/08/130805092634.htm
University of Eastern Finland. "Not only bone density, but also quality of bone predicts fracture risk." ScienceDaily. www.sciencedaily.com/releases/2013/08/130805092634.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com
How A 'Rule Of Thumb' Could Slow Down Drinking

How A 'Rule Of Thumb' Could Slow Down Drinking

Newsy (Aug. 28, 2014) A study suggests people who follow a "rule of thumb" when pouring wine dispense less than those who don't have a particular amount in mind. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins