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Alzheimer disease and Parkinson disease do not appear to share common genetic risk

Date:
August 5, 2013
Source:
American Medical Association (AMA)
Summary:
Scientists have examined the genetic overlap between Parkinson disease (PD) and Alzheimer disease (AD).

A study by Valentina Moskvina, Ph.D., of the Cardiff University School of Medicine, Wales, United Kingdom, and colleagues, examined the genetic overlap between Parkinson disease (PD) and Alzheimer disease (AD).

Data sets from the United Kingdom, Germany, France and the United States were used to perform a combined genome-wide association analysis (GWA). The GWA study of AD included 3,177 patients with AD and 7,277 control patients, and the GWA analysis for PD included 5,333 patients with PD and 12,298 control patients.

The gene-based analyses resulted in no significant evidence that supported the presence of loci (location of gene) that were associated with increased risk for both PD and AD, according to the study results.

"Our findings therefore imply that loci that increase the risk of both PD and AD are not widespread and that the pathological overlap could instead be 'downstream' of the primary susceptibility genes that increase the risk of each disease," the study concludes.


Story Source:

The above story is based on materials provided by American Medical Association (AMA). Note: Materials may be edited for content and length.


Journal Reference:

  1. Valentina Moskvina et al. Analysis of Genome-Wide Association Studies of Alzheimer Disease and of Parkinson Disease to Determine If These 2 Diseases Share a Common Genetic Risk. JAMA Neurol., 2013 DOI: 10.1001/jamaneurol.2013.448

Cite This Page:

American Medical Association (AMA). "Alzheimer disease and Parkinson disease do not appear to share common genetic risk." ScienceDaily. ScienceDaily, 5 August 2013. <www.sciencedaily.com/releases/2013/08/130805222655.htm>.
American Medical Association (AMA). (2013, August 5). Alzheimer disease and Parkinson disease do not appear to share common genetic risk. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2013/08/130805222655.htm
American Medical Association (AMA). "Alzheimer disease and Parkinson disease do not appear to share common genetic risk." ScienceDaily. www.sciencedaily.com/releases/2013/08/130805222655.htm (accessed April 16, 2014).

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