Featured Research

from universities, journals, and other organizations

Novel way gene controls stem cell self-renewal

Date:
August 25, 2013
Source:
University Health Network (UHN)
Summary:
Stem cell scientists have discovered the gene GATA3 has a role in how blood stem cells renew themselves, a finding that advances the quest to expand these cells in the lab for clinical use in bone marrow transplantation, a procedure that saves thousands of lives every year.

Stem cell scientists at the Princess Margaret Cancer Centre have discovered the gene GATA3 has a role in how blood stem cells renew themselves, a finding that advances the quest to expand these cells in the lab for clinical use in bone marrow transplantation, a procedure that saves thousands of lives every year.

The research, published online today in Nature Immunology, provides an important piece in the puzzle of understanding the mechanisms that govern the blood stem cell self-renewal process, says principal investigator Norman Iscove, Senior Scientist at the Princess Margaret, University Health Network (UHN). Dr. Iscove is also an investigator at UHN's McEwen Centre for Regenerative Medicine and a Professor in the Faculty of Medicine, University of Toronto.

"Researchers have known for a long time that stem cells can increase their numbers in the body through self-renewal; however, it has proven very difficult to establish conditions for self-renewal in the laboratory," says Dr. Iscove. Indeed, he explains, the quest to do so has been a holy grail for stem cell researchers because the very effectiveness, safety and availability of the transplantation procedure depend on the number of stem cells available to transplant.

In the lab and using genetically engineered mice, the Iscove team zeroed in on GATA3 and determined that interfering with its function causes stem cells to increase their self-renewal rate and thereby results in increased numbers of stem cells. Dr. Iscove expects scientists will be able to use this new information to improve their ability to grow increased numbers of blood stem cells for use in bone marrow transplantation and possibly, gene therapy.

Dr. Iscove's research is a new page in the growing volume of stem cell science that began here in 1961 with the ground-breaking discovery of blood-forming stem cells by Drs. James Till and the late Ernest McCulloch. Their discovery changed the course of cancer research and laid the foundation for bone marrow transplantation in leukemia patients, as well as for many other types of current disease research.


Story Source:

The above story is based on materials provided by University Health Network (UHN). Note: Materials may be edited for content and length.


Journal Reference:

  1. Catherine Frelin, Robert Herrington, Salima Janmohamed, Mary Barbara, Gary Tran, Christopher J Paige, Patricia Benveniste, Juan-Carlos Zuρiga-Pflόcker, Abdallah Souabni, Meinrad Busslinger, Norman N Iscove. GATA-3 regulates the self-renewal of long-term hematopoietic stem cells. Nature Immunology, 2013; DOI: 10.1038/ni.2692

Cite This Page:

University Health Network (UHN). "Novel way gene controls stem cell self-renewal." ScienceDaily. ScienceDaily, 25 August 2013. <www.sciencedaily.com/releases/2013/08/130825171522.htm>.
University Health Network (UHN). (2013, August 25). Novel way gene controls stem cell self-renewal. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2013/08/130825171522.htm
University Health Network (UHN). "Novel way gene controls stem cell self-renewal." ScienceDaily. www.sciencedaily.com/releases/2013/08/130825171522.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) — Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) — Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) — According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) — The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins