Featured Research

from universities, journals, and other organizations

Can medication slow growth of abdominal aortic aneurysms?

Date:
August 29, 2013
Source:
University of Michigan Health System
Summary:
Non-invasive treatment of abdominal aortic aneurysm clinical trial (N-TA^3CT) investigates what could be the first medical therapy available in the high-stakes course of treating aortic aneurysms.

A new clinical study at the University of Michigan Health System will test the ability of a once daily dose of doxycycline to reduce the growth of small abdominal aortic aneurysms.

An abdominal aortic aneurysm is a bulge in a section of the aorta, the body's main artery. The risk of a rupture is unpredictable, and few patients survive when they do.

The U-M's Frankel Cardiovascular Center is the only health center in the state selected to participate in the national clinical trial investigating what could be the first medical therapy available in the high-stakes course of treating aneurysms.

Surgical repair may become necessary when an aortic aneurysm reaches a certain size or interferes with surrounding blood vessels or organs, but surgery is not an option for all aortic patients.

"It's a really exciting trial examining options for the patients who are relegated to watching and waiting," says University of Michigan vascular surgeon Jonathan Eliason, M.D., associate professor of surgery. "If this medicine is effective in slowing aneurysm growth rates, it could revolutionize our treatment of AAAs."

The clinical trial Non-Invasive Treatment of Abdominal Aortic Aneurysms (N-TA^3CT) will determine whether treatment with doxycycline, a microbial drug that in animal studies inhibited the action of matrix metalloproteinase (MMP), an enzyme linked to the development of AAAs, will lead to reduced growth of an aneurysm.

"The aim is to see if the data gained from animal studies for slowing aneurysm growth holds true for humans," says Eliasion.

A normal abdominal aorta is approximately 2.0 cm in diameter -- about the size of a quarter -- but an aneurysm puts stress on the artery walls. The risk of rupture for an AAA over 5.5 cm in diameter is 9 to 10 percent, and over 7 cm the risk increases to more than 30 percent.

AAA is more common in men and in those age 65 and older. According to the Centers for Disease Control and Prevention, the most effective way to prevent aortic aneurysms is reducing risk factors including quitting smoking and controlling high blood pressure and high cholesterol.


Story Source:

The above story is based on materials provided by University of Michigan Health System. Note: Materials may be edited for content and length.


Cite This Page:

University of Michigan Health System. "Can medication slow growth of abdominal aortic aneurysms?." ScienceDaily. ScienceDaily, 29 August 2013. <www.sciencedaily.com/releases/2013/08/130829092646.htm>.
University of Michigan Health System. (2013, August 29). Can medication slow growth of abdominal aortic aneurysms?. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2013/08/130829092646.htm
University of Michigan Health System. "Can medication slow growth of abdominal aortic aneurysms?." ScienceDaily. www.sciencedaily.com/releases/2013/08/130829092646.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins