Featured Research

from universities, journals, and other organizations

Potential diagnostic marker for zinc status offers insights into the effects of zinc deficiency

Date:
August 29, 2013
Source:
Federation of American Societies for Experimental Biology
Summary:
According to new research, a drop in blood zinc levels does not directly harm the blood vessel cells. Rather, zinc regulates the production of a small molecular compound, which circulates in the blood, causing harmful blood vessel cell effects. Additionally, not only will having adequate amounts of zinc prevent the creation of this compound, but it can protect you when the compound is circulating in your blood.

According to new research published in The FASEB Journal, a drop in blood zinc levels does not directly harm the blood vessel cells. Rather, zinc regulates the production of a small molecular compound, which then circulates in the blood and causes harmful blood vessel cell effects. Additionally, not only will having adequate amounts of zinc prevent the creation of this compound, but it can protect you when the compound is circulating in your blood.

Related Articles


"Zinc deficiency afflicts two billion people worldwide and our study has revealed a zinc-regulated small compound in blood that mediates the harmful effects of zinc deprivation," said John H. Beattie, Ph.D., a researcher involved in the work from the Rowett Institute of Nutrition and Health at the University of Aberdeen in Aberdeen, U.K. "Measurement of this compound in blood may prove very valuable, not only in assessing, for example, the risk of developing heart attack or stroke, but also as a diagnostic test for zinc status."

To make this discovery, Beattie and colleagues cultured cells from rat blood vessels and exposed them for 24 hours to the blood plasma from rats that had been given food low or adequate in zinc. Then they examined the gene expression profile to identify which genes changed when exposed to blood plasma from low zinc rats. Dramatic changes in some gene activities were found when comparing blood plasma treatments from low and adequate zinc rats. Then the scientists removed the zinc from the zinc-adequate blood plasma and saw that it had no effect on gene activity, suggesting that that there was a harmful compound produced in response to zinc deficiency and that its effects on blood vessel cells is abolished by zinc.

"Most people might think of zinc as a kind of food supplement," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "but zinc deficiency is a serious matter. Understanding how zinc deficiency affects the body is important, not just because it can help us how to treat this deficiency, but also because it presents a new way to detect low zinc in the body that is faster and easier than current methods."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. O. Ou, K. Allen-Redpath, D. Urgast, M.-J. Gordon, G. Campbell, J. Feldmann, G. F. Nixon, C.-D. Mayer, I.-S. Kwun, J. H. Beattie. Plasma zinc's alter ego is a low-molecular-weight humoral factor. The FASEB Journal, 2013; 27 (9): 3672 DOI: 10.1096/fj.13-228791

Cite This Page:

Federation of American Societies for Experimental Biology. "Potential diagnostic marker for zinc status offers insights into the effects of zinc deficiency." ScienceDaily. ScienceDaily, 29 August 2013. <www.sciencedaily.com/releases/2013/08/130829110428.htm>.
Federation of American Societies for Experimental Biology. (2013, August 29). Potential diagnostic marker for zinc status offers insights into the effects of zinc deficiency. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2013/08/130829110428.htm
Federation of American Societies for Experimental Biology. "Potential diagnostic marker for zinc status offers insights into the effects of zinc deficiency." ScienceDaily. www.sciencedaily.com/releases/2013/08/130829110428.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins